Objective
The aim of this study was to compare microcirculatory parameters in normal versus
alveolar cleft gingiva in children selected for secondary bone grafting procedures.
Study Design
This study included 11 consecutive patients with complete unilateral alveolar clefts
who required secondary bone grafting procedures. In a split-mouth design, noninvasive
real-time simultaneous measurements among tissue oxygen saturation (StO2), hemoglobin level (rHb), and blood flow parameters were obtained from normal and
alveolar cleft gingiva using spectrophotometry and laser Doppler flowmetry. Subsequent
noninvasive capillary density measurements and tissue microangioarchitecture were
assessed using sidestream dark-field imaging.
Results
There were no significant differences in StO2 and rHb between normal and alveolar cleft gingiva. Blood flow, blood flow velocity,
and capillary density were significantly decreased in alveolar cleft gingiva (P < 0.05).
Conclusions
Alveolar cleft reconstructions alter gingival microperfusion properties, and microvascular
changes adapt to conserve peak oxygen saturation.
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Article info
Publication history
Published online: September 03, 2012
Accepted:
April 13,
2012
Received in revised form:
March 18,
2012
Received:
February 16,
2012
Footnotes
Conflict of Interest In addition to his listed affiliation, Can Ince is inventor of the sidestream dark-field imaging technique and, therefore, holds patents and stock in this technology. The remaining authors indicate they have no personal financial relationships or potential conflicts of interest to declare.
Identification
Copyright
© 2013 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
