The need to be aware of the dynamics of cartilage development and growth is encountered
by surgeons whenever they attempt to correct craniofacial defects such as unilateral
or bilateral cleft lip/cleft palate or midfacial injuries after trauma. Within the
craniofacial region, the nasal septal cartilage and the sphenoethmoidal and sphenooccipital
cranial synchondroses are distinguished from other craniofacial cartilages in possessing
intrinsic growth potential. Indeed, growth of the nasal septal cartilage outstrips
the growth of other skeletal and soft tissues in the midface to such an extent that
it is the pacemaker for growth of the face and anterior portion of the skull. We revisit
and reinforce the importance of the nasal septum as pacemaker with analysis of 3 classes
of evidence: in vivo growth of the nasal septum in nonhuman mammalian models; composition
and in vitro growth of nasal septal cartilage or chondrocytes; and experience from
the surgical repair of unilateral or bilateral facial clefts.
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References
- The cartilage of the nasal septum (a contribution to the study of facial growth).Brit. Dental J. 1953; 95: 37-43
- The growth of the human face.Proc R Soc Med. 1954; 47 (1954): 91-100
- The nasal septum: an endochondral growth center.J Dent Res. 1961; 40: 625
- The role of genetic and local environmental factors in the control of postnatal craniofacial morphogenesis.Acta Morphol Neerl Scand. 1972; 10: 37-47
- Factors controlling skeletal morphogenesis.in: Dixon A.D. Sarnat B.G. Factors and mechanisms influencing bone growth. Alan R. Liss, New York1982: 1-17
- The significance of van Limborgh's approach to craniofacial biology.Acta Morphol Neerl Scand. 1985; 23: 317-324
- What is bone growth?.in: Dixon A.D. Sarnat B.G. Hoyte D.A.N. Fundamentals of bone growth: methodology and applications. CRC Press, Boca Raton1991: 605-612
- Bones and cartilage: developmental and evolutionary skeletal biology.Elsevier Academic, London2005
- Prenatal development of the human mandible.Anat Rec. 2001; 263: 314-325
- A model for development and evolution of complex morphological structures.Biol Rev Camb Philos Soc. 1991; 66: 101-157
- Development of the facial midline.J Craniofac Surg. 2002; 13: 129-187
- New directions in craniofacial morphogenesis.Dev Biol. 2010; 341: 84-94
- Postnatal growth of the human septal cartilage.Acta Otolaryngol (Stock). 1984; 97: 131-136
- A compositional analysis of human nasal septal cartilage.Arch Facial Plast Surg. 2003; 5: 53-58
- The growth of the nasal septum in the 6-9 week period of foetal development—warfarin embryopathy offers a new insight into prenatal facial development.Aust Dent J. 2004; 49: 171-176
- Clonal proliferation and cell density of chondrocytes isolated from human fetal epiphyseal, human adult articular and nasal septal cartilage.Growth. 1985; 49: 229-245
- Histological analysis of the postnatal development of the nasal septum.Angle Orthod. 1977; 47: 83-96
- Growth characteristics of the human nasal septum.Rhinology. 1996; 34: 78-82
- A cephalometric analysis of nasal septal growth.Clin Otolaryngol Allied Sci. 1977; 22: 453-458
- Human nasal septal cartilage: analysis of intracellular enzyme activities, glycogen content, cell density and clonal proliferation of septal chondrocytes of healthy adults and acromegalic patients.Connect Tissue Res. 1989; 18: 243-254
- An immunohistochemical study of localization of type I and type II collagens in mandibular condylar cartilage compared with tibial growth plate.Histochemistry. 1990; 93: 593-600
- A comparison of the immunohistochemical localization of type I and type II collagens in craniofacial cartilages of the rat.Acta Anat. 1992; 144: 59-64
- A model for development and evolution of complex morphological structures.Biol Rev Camb Philos Soc. 1991; 66: 101-157
- Comparison of amounts and properties of collagen and proteoglycans in condylar, costal and nasal cartilages.Cells Tissues Organs. 1999; 164: 30-36
- A compositional analysis of human nasal septal cartilage.Arch Facial Plast Surg. 2003; 5: 53-58
- Effects of growth factors and interleukin-1 alpha on proteoglycan and type II collagen turnover in bovine nasal and articular chondrocyte pellet cultures.Endocrinology. 1996; 137: 3557-3565
- Balanced facial growth: A schematic interpretation.Oral Surg Oral Med Oral Pathol. 1987; 63: 637-644
- The effect of nasomaxillary injury on future facial growth.Oral Surg Oral Med Oral Pathol. 1988; 66: 525-530
- Developmental field reassignment in unilateral cleft lip: reconstruction of the premaxilla.Indian J Plast Surg. 2007; 40: 75-103
- Primary unilateral cleft lip/nose repair via the Delaire technique.in: Ghali G. Atlas of the oral and maxillofacial clinics of North America. Vol. 17. Elsevier, Philadelphia2009: 125-135
- Correlation of asymmetric facial growth with deviated nasal septum.Laryngoscope. 2011; 121: 1144-1148
- Rhinoplasty for preventing nasal cartilage growth.Aesthet Plast Surg. 1980; 4: 199-204
- Rhinosurgery in children: basic concepts.Facial Plast Surg. 2007; 23: 219-230
- Development of the facial midline.J Craniofac Surg. 2002; 13: 129-187
- Developmental field reassignment in unilateral cleft lip: reconstruction of the premaxilla.Indian J Plast Surg. 2007; 40: 75-103
- The influence of partial resections of the nasal septal cartilage on the growth of the upper jaw and the nose: an experimental study in rabbits.Clin Otolaryngol. 1980; 5: 291-302
- Effects and noneffects of personal environmental experimentation on postnatal craniofacial growth.J Craniofac Surg. 2001; 12: 205-217
- Nasal septal and premaxillary developmental integration: implications for facial reduction in Homo.Anat Rec. 2011; 194: 68-78
- Growth of the nasal septal cartilage of the rat in vitro.J Anat. 1986; 144: 99-111
- Influence of the nasal septum on maxillonasal growth in patients with congenital labiomaxillary cleft.Cleft Palate J. 1986; 23: 270-277
- Cells Tissues Organs. 2004; 176: 1-165
- Primary bilateral cleft lip/nose repair via the Delaire technique.in: Ghali G. Atlas of the oral and maxillofacial clinics of North America. Vol. 17. Elsevier, Philadelphia2009: 137-146
- Growth and development of the maxillofacial region.in: Peterson L.J. Principles of Oral and Maxillofacial Surgery. Vol. 3. Lippincott, Philadelphia1992: 1211-1236
- Growth activity in human septal cartilage: age-dependent incorporation of labeled sulfate in different anatomic locations.Plast Reconstruct Surg. 1983; 71: 167-170
Article info
Publication history
Published online: September 28, 2012
Accepted:
May 7,
2012
Received:
April 6,
2012
Footnotes
B.K.H. acknowledges on-going research support from Natural Sciences and Engineering Research Council of Canada (grant no. A5056).
Identification
Copyright
© 2013 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
