Objective
The objective of this preliminary study was to evaluate the expression of matrix metalloproteinases
(MMPs), tissue inhibitors of metalloproteinases (TIMPs) and growth factors in keratocystic
odontogenic tumors (KOTs).
Study Design
The expression of MMPs, TIMPs, growth factors, and the extracellular signal–regulated
kinase (ERK) 1/2 signaling pathway were assessed by immunohistochemistry in 15 cases
of KOT and 4 cases of calcifying cystic odontogenic tumor (CCOT).
Results
KOT samples expressed significantly higher amounts of MMPs, TIMPs, growth factors,
epidermal growth factor receptor (EGFR), and ERK compared with CCOT samples, with
the exception of MMP-2 and TIMP-1.
Conclusions
MMP-9, TIMP-2, EGF and transforming growth factor α act together and likely regulate
the proliferation and aggressiveness of KOT. ERK-1/2 serves as the transducer of signals
generated by these proteins, which signal through the common receptor, EGFR. This
process may be related to the increased proliferation and aggressiveness observed
in KOT.
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Article info
Publication history
Accepted:
June 16,
2012
Received in revised form:
June 15,
2012
Received:
February 10,
2012
Identification
Copyright
© 2012 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
