Objective
Recurrent aphthous stomatitis (RAS) is a common oral mucosal disease, yet effective
therapeutic approaches are lacking. This study aimed to determine the effects of application
of berberine gelatin in the treatment of minor RAS (MiRAS).
Methods
A randomized, double-blind, placebo-controlled, clinical trial was performed. The
gelatin containing berberine (5 mg/g) or vehicle only was applied 4 times per day
for 5 days. Clinical evaluation included pain level, size, erythema, and exudation
of certain ulcers on days 1, 2, 4, and 6.
Results
A total of 84 subjects fulfilled the study without obvious side effects. Berberine
gelatin treatment reduced the ulcer pain score compared with placebo gelatin (P < 0.05). Ulcer size was significantly reduced (P < 0.05) and lower erythema (P < 0.05) and exudation (P < 0.05) levels were associated with berberine treatment.
Conclusions
Berberine gelatin may be a safe and effective treatment for MiRAS.
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Article info
Publication history
Published online: December 14, 2012
Accepted:
September 9,
2012
Received in revised form:
September 2,
2012
Received:
July 11,
2012
Footnotes
Competing interests. The authors state that they have no conflict of interest.
Identification
Copyright
© 2013 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
