Kaposi sarcoma is the most common HIV-associated neoplasm, frequently presenting with
oral mucosal involvement. This retrospective study aimed to assess and highlight the
histomorphological spectrum of oral Kaposi sarcoma. A total of 135 cases diagnosed
between 1990 and 2011 were retrieved from the archives of the Oral and Dental Hospital
of the University of Pretoria, South Africa. Following histologic review, each case
was placed into 1 of 7 categories based on the predominant pattern of growth. These
histologic divisions included lesions designated as solid, lymphangioma-like, telangiectatic,
desmoplastic, lymphangiectatic, ecchymotic, and anaplastic. The presence of coexistent
pathology was identified in 25 cases, largely represented by superimposed candidiasis.
Concomitant cytomegalovirus and non-necrotizing granulomatous inflammation were also
observed. Although the prognostic significance of these variants is yet to be determined,
the appreciation and recognition of such morphologic diversity remains essential in
distinguishing these lesions from possible mimickers.
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Article info
Publication history
Accepted:
November 7,
2012
Received in revised form:
October 25,
2012
Received:
August 29,
2012
Footnotes
Supported by a grant from the National Research Foundation of South Africa.
Identification
Copyright
© 2013 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
