Objective
We report the clinical features and management outcomes in 7 patients with everolimus-related
stomatitis.
Study design
Fifteen women with hormone-receptor-positive advanced breast cancer receiving everolimus
combined with exemestane were prospectively evaluated to assess the development of
stomatitis. Oral ulcers were diagnosed based on established criteria.
Results
Seven patients developed stomatitis (46.6%). All patients were treated with topical
dexamethasone solution, while everolimus was temporarily discontinued in 4 patients.
Stomatitis resolved within 1-2 weeks. Two of the 4 patients, who had interrupted everolimus,
developed recurrent stomatitis following drug resume and everolimus was again discontinued
and restarted after 2 weeks. To date, 5 patients receive everolimus in full dose.
The 2 patients, who developed recurrent stomatitis, received a reduced dose.
Conclusions
Everolimus-related oral ulcers were frequent and led to dose modifications. Controlled
trials, endorsing a consensus in terminology, are needed to evaluate measures on prevention
and management of this unique toxicity.
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Article info
Publication history
Published online: May 06, 2013
Accepted:
February 23,
2013
Received in revised form:
February 10,
2013
Received:
December 7,
2012
Identification
Copyright
© 2013 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
