Abstract| Volume 119, ISSUE 3, e207, March 2015

Intraoral Malignant Melanoma: An Illustrative Report of Two Case

      Melanomas develop from melanocytes which are derived from the neural crest. Primary oral mucosal melanoma is rare, accounts for 0.5% of all oral cancers. Oral subtype has the worst prognosis compared to other mucosal melanoma. We report an unusual case of oral mucosal melanoma of the gingiva with the main characteristics of an in situ and invasive lesion. Case1: The 3 mm incisional gingival biopsy was taken from a 23 year-old man. A presumptive clinical diagnosis of odontogenic cyst was made. Case2: The excisional gingival biopsy was taken from a 42 year-old man.The biopsy was 2,5 × 2cm in diameter and 2 mm elevated from mucosal surface. The histological examination showed a downward streaming and pigmentation in the dermis of the tumor cells. Immunohistochemical studies showed positivity for HMB 45, Melan-A, S-100 marker.
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