Melanomas develop from melanocytes which are derived from the neural crest. Primary
oral mucosal melanoma is rare, accounts for 0.5% of all oral cancers. Oral subtype
has the worst prognosis compared to other mucosal melanoma. We report an unusual case
of oral mucosal melanoma of the gingiva with the main characteristics of an in situ
and invasive lesion. Case1: The 3 mm incisional gingival biopsy was taken from a 23
year-old man. A presumptive clinical diagnosis of odontogenic cyst was made. Case2:
The excisional gingival biopsy was taken from a 42 year-old man.The biopsy was 2,5
× 2cm in diameter and 2 mm elevated from mucosal surface. The histological examination
showed a downward streaming and pigmentation in the dermis of the tumor cells. Immunohistochemical
studies showed positivity for HMB 45, Melan-A, S-100 marker.
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© 2015 Published by Elsevier Inc.
