Oral and maxillofacial pathology Online only article| Volume 122, ISSUE 3, e86-e92, September 2016

Download started.


Adenomatoid odontogenic tumor with peripheral cemento-osseous reactive proliferation: report of 2 cases and review of the literature

Published:December 18, 2015DOI:
      Two cases of a rare variant of adenomatoid odontogenic tumor encompassed by a prominent reactive cemento-osseous proliferation are reported. This unique variant of adenomatoid odontogenic tumor has only been seen twice in the authors' collective experience. Literature documenting the histopathologic patterns of adenomatoid odontogenic tumor and the occurrence of other combined lesions other is reviewed and discussed.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


        • James W.
        • Forbes J.G.
        An epithelial odontome.
        Proc R Soc Med. 1909; 2: 166-175
        • Ide F.
        • Muramatsu T.
        • Ito Y.
        • et al.
        An expanded and revised early history of the adenomatoid odontogenic tumor.
        Oral Surg Oral Med Oral Pathol Oral Radiol. 2013; 115: 646-651
        • Nakayama M.
        On cystic epithelial tumors of the maxilla.
        Nippon Jibiinkoka Gakkai Kaihou. 1903; 9 ([in Japanese]): 11-70
        • Wohl M.G.
        Tooth germ cysts of the jaw.
        Ann Surg. 1916; 64: 672-679
        • Stafne E.C.
        Epithelial tumors associated with developmental cysts of the maxilla. Report of three cases.
        Oral Surg. 1948; 1: 887-894
        • Bernier J.L.
        • Tiecke R.W.
        J Oral Surg. 1950; 8: 259-261
        • Thoma K.H.
        Oral Surg. 1955; 8: 441-444
        • Gorlin R.J.
        • Chaudhry A.P.
        • Pindborg J.J.
        Odontogenic tumors: Classification, histopathology, and clinical behavior in man and domesticated animals.
        Cancer. 1961; 14: 73-101
        • Shafer W.G.
        • Hine M.K.
        • Levy B.M.
        Tumors and cysts of odontogenic origin.
        in: A Textbook of Oral Pathology. 2nd ed. WB Saunders, Philadelphia1963: 218-219
        • Philipsen H.P.
        • Birn H.
        The adenomatoid odontogenic tumor.
        Acta Pathol Microbiol Scand. 1969; 75: 375-398
        • Pindborg J.J.
        • Kramer I.R.H.
        Histological typing of odontogenic tumors, jaw cysts and allied lesions.
        in: International Histological Classification of Tumours, No. 5. World Health Organization, Geneva, Switzerland1971
        • Rick G.M.
        Adenomatoid odontogenic tumor.
        Oral Maxillofac Surg Clin North Am. 2004; 16: 333-354
        • Philipsen H.P.
        • Reichart P.A.
        • Zhang K.H.
        • Nikai H.
        • Yu Q.X.
        Adenomatoid odontogenic tumor: Biologic profile based on 499 cases.
        J Oral Pathol Med. 1991; 20: 149-158
        • Philipsen H.P.
        • Reichart P.A.
        Adenomatoid odontogenic tumor: facts and figures.
        Oral Oncol. 1998; 35: 125-131
        • de Matos F.R.
        • Nonaka C.F.
        • Pinto L.P.
        Adenomatoid odontogenic tumor: retrospective study of 15 cases with emphasis on histopathologic features.
        Head Neck Pathol. 2012; 6: 430-437
        • Damm D.D.
        • White D.K.
        • Drummond J.F.
        • et al.
        Combined epithelial odontogenic tumor: adenomatoid odontogenic tumor and calcifying epithelial odontogenic tumor.
        Oral Surg Oral Med Oral Pathol. 1983; 55: 487-496
        • Okada Y.
        • Mochizuki K.
        • Sugimura M.
        • et al.
        Odontogenic tumor with combined characteristics of adenomatoid odontogenic and calcifying epithelial odontogenic tumors.
        Pathol Res Pract. 1987; 182: 647-657
        • Takeda Y.
        • Kudo K.
        Adenomatoid odontogenic tumor associated with calcifying epithelial odontogenic tumor.
        Int J Oral Maxillofac Surg. 1986; 15: 469-473
        • Miyake M.
        • Nagahata S.
        • Nishihara J.
        • et al.
        Combined adenomatoid odontogenic tumor and calcifying epithelial odontogenic tumor: report of case and ultrastructural study.
        J Oral Maxillofac Surg. 1996; 54: 788-793
        • Montes Ledesma C.
        • Mosqueda Taylor A.
        • Romero de León E.
        • et al.
        Adenomatoid odontogenic tumour with features of calcifying epithelial odontogenic tumour. (The so-called combined epithelial odontogenic tumour.) Clinico-pathological report of 12 cases.
        Eur J Cancer B Oral Oncol. 1993; 29B: 221-224
        • Mosqueda-Taylor A.
        • Carlos-Bregni R.
        • Montes Ledesma C.
        • et al.
        Calcifying epithelial odontogenic tumor-like areas are common findings in adenomatoid odontogenic tumors and not a specific entity.
        Oral Oncol. 2005; 41: 214-215
        • Dunlap C.L.
        • Fritzlen T.J.
        Cystic odontoma with concomitant adenoameloblastoma (adenoameloblastic odontoma).
        Oral Surg Oral Med Oral Pathol. 1972; 34: 450-456
        • Ide F.
        • Kusama K.
        Adenomatoid odontoma.
        Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2002; 94: 149-150
        • Allen C.M.
        • Neville B.W.
        • Hammond H.L.
        Adenomatoid dentinoma. Report of four cases of an unusual odontogenic lesion.
        Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1998; 86: 313-317
        • Takeda Y.
        Induction of osteodentin and abortive enamel in adenomatoid odontogenic tumor.
        Ann Dent. 1995; 54: 61-63
        • Li B.B.
        • Xie X.Y.
        • Jia S.N.
        Adenomatoid odontogenic tumor with fibro-osseous reaction in the surrounding tissue.
        J Craniofac Surg. 2013; 24: e100-101
        • Das D.K.
        Psammoma body: a product of dystrophic calcification or of a biologically active process that aims at limiting the growth and spread of tumor?.
        Diagn Cytopathol. 2009; 37: 534-541
        • Gardner D.G.
        • Sapp J.P.
        Regional odontodysplasia.
        Oral Surg Oral Med Oral Pathol. 1973; 35: 351-365
        • Gardner D.G.
        • Radden B.
        Multiple calcifying hyperplastic follicles.
        Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1995; 79: 603-606
        • Geraldo A.F.
        • Mendes Dos Santos C.
        • Tavares J.
        • et al.
        Benign fibro-osseous lesions of the craniofacial complex with aneurysmal bone cyst formation.
        Acta Med Port. 2012; 25: 55-59
        • Chadwick J.W.
        • Alsufyani N.A.
        • Lam E.W.
        Clinical and radiographic features of solitary and cemento-osseous dysplasia-associated simple bone cysts.
        Dentomaxillofac Radiol. 2011; 40: 230-235
        • Mahomed F.
        • Altini M.
        • Meer S.
        • et al.
        Cemento-osseous dysplasia with associated simple bone cysts.
        J Oral Maxillofac Surg. 2005; 63: 1549-1554
        • Kaplan I.
        • Manor I.
        • Yahalom R.
        • et al.
        Central giant cell granuloma associated with central ossifying fibroma of the jaws: a clinicopathologic study.
        Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007; 103e: e35-e41
        • Crusoé-Rebello I.
        • Torres M.G.
        • Burgos V.
        • et al.
        Hybrid lesion: Central giant cell granuloma and benign fibro-osseous lesion.
        Dentomaxillofac Radiol. 2009; 38: 421-425