We present a case of sclerosing odontogenic carcinoma (SOC) occurring on the hard
palate of a 43-year-old female. The tumor presented as an asymptomatic firm swelling
and histopathologically was characterized by widely dispersed nests and cords of bland
cells infiltrating between hyalinized collagen fibers. Prominent perineural and intraneural
invasion and erosion of bone was noted. The tumor cells showed staining with antibodies
to pan-cytokeratin (PanCK), cytokeratin 19 (CK19), cytokeratin 5/6 (CK5/6), cytokeratin
14 (CK14), p63 and E-cadherin, but no staining with antibodies to carcinoembryonic
antigen (CEA), cytokeratin 7 (CK7), cytokeratin 20 (CK20), estrogen receptor (ER),
progesterone receptor (PR) or S100. Staining for mucin with alcian blue/periodic acid–Schiff
with diastase was equivocal, with no definite evidence of mucin or muciphages. An
initial diagnosis of adenocarcinoma NOS was made upon incisional biopsy, with the
prominent filing pattern and cytoplasmic vacuolization prompting consideration of
metastatic breast cancer in the first instance. The true nature of the tumor became
clear after staging investigations and surgical resection. The patient was treated
by surgery alone and is disease-free after 17 months.
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Article info
Publication history
Published online: July 23, 2016
Accepted:
July 13,
2016
Received in revised form:
July 1,
2016
Received:
February 26,
2016
Identification
Copyright
© 2016 Elsevier Inc. All rights reserved.
