Objective
To investigate the effectiveness of turmeric with black pepper and nigella sativa
in oral submucous fibrosis (OSMF).
Study Design
Forty OSMF patients were randomly divided into two groups. The study was performed
under a double-blind, randomized design. Group A received turmeric with black pepper
and group B received nigella sativa for 3 months. Clinical evaluation was done every
15 days. Patients' serum superoxide dismutase (SOD) levels were assessed before and
after treatment and also compared with healthy controls. The response to treatment
was analyzed using analysis of variance, paired t test, and unpaired t test.
Results
After the treatment, groups A and B showed 3.85 ± 0.22 mm and 3.6 ± 0.07 mm improvement
in mouth opening, respectively (P < .01); 87.90% and 78.91% reduction in burning sensation, respectively (P < .01); and +0.62 U/mL and +0.74 U/mL improvement in serum SOD levels, respectively
(P < .05). The maximum mouth opening achieved was 8 mm in group A and 7 mm in group
B. The mean pretreatment SOD level for controls and patients was 3.61 ± 0.24 U/mL
in group A and 2.63 ± 0.18 U/mL in group B.
Conclusion
Turmeric with black pepper and nigella sativa improved mouth opening, burning sensation,
and SOD levels in the present OSMF study patients; however, further investigations
are needed.
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Article info
Publication history
Published online: August 06, 2016
Accepted:
July 25,
2016
Received in revised form:
July 8,
2016
Received:
April 13,
2016
Identification
Copyright
© 2016 Elsevier Inc. All rights reserved.
