Objective
To investigate toll-like receptor 4 (TLR4) and nuclear factor-κBp65 (NF-κBp65) expression
in oral squamous cell carcinoma (OSCC) tissues and the effects of their expression
on the outcomes in patients with OSCC.
Study Design
TLR4 and NF-κBp65 expression was assessed in 110 patients with OSCC and in 32 normal
oral mucosal samples using immunohistochemistry. Correlations between their expression
and clinicopathologic parameters, including disease-free survival, disease-specific
survival, and overall survival, were analyzed.
Results
High TLR4/NF-κBp65 expression was increased in OSCC tissues compared with normal oral
mucosal tissues (all P < .05). High cytoplasmic TLR4 and NF-κBp65 expression was significantly correlated
with the primary tumor stage, pN stage, differentiation, invasion depth, and pTNM
stage (all P < .05). Cytoplasmic TLR4 expression was associated with NF-κBp65 expression in OSCC
(all P < .05). Univariate analysis revealed that high cytoplasmic TLR4 and nuclear NF-κBp65
expression was significantly associated with lower disease-free survival, disease-specific
survival, and overall survival rates (all P < .001). Further, multivariate analyses identified high cytoplasmic TLR4 and nuclear
NF-κBp65 expression as independent prognostic factors (all P < .05).
Conclusions
The current findings suggest that the TLR4/NF-κBp65 signaling pathway is associated
with survival of patients with OSCC and that it may serve as a potential therapeutic
target.
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Article info
Publication history
Published online: August 08, 2016
Accepted:
August 1,
2016
Received in revised form:
July 30,
2016
Received:
January 31,
2016
Footnotes
This research was supported by the Nature Science Foundation of Heilongjiang Province (H201357) and the Jiamusi University Graduate Student Science and Technology Innovation Project (LM 2014-040).
Identification
Copyright
© 2016 Elsevier Inc. All rights reserved.
