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“A randomized double-blind, multiple-arm trial comparing the efficacy of submucosal injections of hyaluronidase, dexamethasone, and combination of dexamethasone and hyaluronidase in the management of oral submucous fibrosis”—a commentary

Published:August 31, 2016DOI:https://doi.org/10.1016/j.oooo.2016.06.098
      To the Editor:
      We congratulate the authors on the report of their randomized, double-blind, multiple-arm clinical trial.
      • Alora Veedu R.
      • Balan A.
      • Sankar S.P.
      A randomized double-blind, multiple-arm trial comparing the efficacy of submucosal injections of hyaluronidase, dexamethasone, and combination of dexamethasone and hyaluronidase in the management of oral submucous fibrosis.
      The article is very informative for clinicians encountering oral submucous fibrosis. We have a few queries for which we seek clarifications from the authors. We request the authors respond to the following questions:
      • 1.
        Without an intragroup analysis, can we conclude that there was significant reduction in tightness of mucosa in all the three groups?
      • 2.
        The total improvement in burning sensation and tightness of mucosa does not appear to match with the total aggregate of baseline—week 2, week 2 to month 1, months 1 to 2, months 2 to 3, and months 3 to 6 for group 1.
      • 3.
        With regard to tightness of mucosa and mouth opening (months 3-6), is it valid to include the group comparisons when one or more groups had mean and standard deviation of 0?
      Thank you.

      Reference

        • Alora Veedu R.
        • Balan A.
        • Sankar S.P.
        A randomized double-blind, multiple-arm trial comparing the efficacy of submucosal injections of hyaluronidase, dexamethasone, and combination of dexamethasone and hyaluronidase in the management of oral submucous fibrosis.
        Oral Surg Oral Med Oral Pathol Oral Radiol. 2015; 120: 588-593

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