Objectives
The aim of this study was to analyze the expression of CD24, CD44, CD133, ALDH1, CD29
(integrin-β1), and Ki-67 in squamous cell carcinoma of the oral cavity and oropharynx.
Study Design
Fifty-two tumors and 21 metastatic lymph nodes were evaluated by using immunohistochemistry.
Results
Seven of 52 cases (13.5%) showed positive cytoplasmic staining of aldehyde dehydrogenase
1; integrin-β1 was expressed in 45 of 50 cases (90%); 30 of 52 cases (57.7%) had positive
membranous staining of CD44; CD24 was expressed in 44 of 50 cases (88%); and three
of 52 cases (5.8%) stained positively for membranous CD133. Median proliferation rate,
measured by Ki-67, was 37.1% for tumors. Five-year cancer-specific survival rates
for the CD44-negative and CD44-positive groups were 74% and 38%, respectively, although
this difference did not reach statistical significance (P = .052).
Conclusions
Our study demonstrated the expression of putative stem cell markers in squamous cell
carcinoma of the oral cavity and oropharynx, with participation of CD44-positive cells
in association with poor survival outcome.
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Article info
Publication history
Published online: September 28, 2016
Accepted:
September 11,
2016
Received in revised form:
August 18,
2016
Received:
May 11,
2016
Footnotes
This work was supported by the CNPq (grant number 475449/2011-8).
Identification
Copyright
© 2016 Elsevier Inc. All rights reserved.
