Intestinal-type adenocarcinoma of the primary salivary glands is extremely rare. So
far, only 11 cases of primary intestinal-type adenocarcinoma of the oral cavity and
major salivary glands have been reported. Two of those tumors arose in the floor of
mouth, 7 in the tongue, and 2 in the major salivary glands. However, it has remained
unclear whether these tumors are derived from mature salivary glands, and primary
intestinal-type adenocarcinoma of the buccal mucosa has not been reported previously.
Here, we present the first documented case of primary intestinal-type adenocarcinoma
arising in a minor salivary gland of the buccal mucosa. Histopathologically, the tumor
resembled a well-differentiated or mucinous colonic adenocarcinoma. Immunohistochemically,
the tumor cells were diffusely positive for AE1/AE3, CAM5.2, CK7, SATB2, β-catenin,
p53, Ki-67, MUC2, and MUC5 AC. CK14 and CK20 were positive in some of the tumor cells.
CDX2, CA19-9, SP-A, TTF-1, PSA, SMA, p63, and cyclin D1 were negative in the tumor
cells. The tumor in the present case may have originated from salivary gland duct
epithelium that underwent transformation to phenotypic intestinal-type epithelium.
In this very rare case of primary intestinal-type adenocarcinoma of the buccal mucosa,
we considered diagnostic markers that could be indicative of mature salivary gland
origin.
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Article info
Publication history
Published online: May 30, 2018
Accepted:
May 21,
2018
Received in revised form:
May 7,
2018
Received:
March 16,
2018
Identification
Copyright
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