Effects of Cannabis Use on Patients Undergoing Office-Based Anesthesia: A Brief Literature Review and Case Report of 50 Outpatient Cases of IV Sedation in Marijuana Users

      Objective: The widespread use of cannabis, including legalization of recreational use in several states, can present problems to the health care practitioner when providing office-based anesthesia. Marijuana is known to have profound effects on the cardiovascular, respiratory, neurocognitive, and autonomic nervous systems. Cardiovascular effects may manifest as tachycardia and increased systolic and diastolic blood pressures as well as possible electrocardiographic changes. Respiratory system effects occur with frequent use of cannabis and include predisposition to bronchospasm, chronic cough, and bronchitis. The physiologic effects of marijuana and its concomitant effects on sedation, as well as the subsequent impairment and the ability to sign informed consent, also need to be considered. The purpose of this study was to review 50 cases of patients undergoing office-based anesthesia with a history significant for marijuana use and to evaluate for preoperative, intraoperative, and postoperative differences to determine the most effective way to consistently achieve adequate and safe sedation in this population.
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