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Objective: The widespread use of cannabis, including legalization of recreational use in several
states, can present problems to the health care practitioner when providing office-based
anesthesia. Marijuana is known to have profound effects on the cardiovascular, respiratory,
neurocognitive, and autonomic nervous systems. Cardiovascular effects may manifest
as tachycardia and increased systolic and diastolic blood pressures as well as possible
electrocardiographic changes. Respiratory system effects occur with frequent use of
cannabis and include predisposition to bronchospasm, chronic cough, and bronchitis.
The physiologic effects of marijuana and its concomitant effects on sedation, as well
as the subsequent impairment and the ability to sign informed consent, also need to
be considered. The purpose of this study was to review 50 cases of patients undergoing
office-based anesthesia with a history significant for marijuana use and to evaluate
for preoperative, intraoperative, and postoperative differences to determine the most
effective way to consistently achieve adequate and safe sedation in this population.
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