Objective
The aim of this study was to investigate the effectiveness of platelet-rich plasma
(PRP) injection after arthrocentesis or arthroscopy in patients with temporomandibular
joint osteoarthritis.
Study Design
Electronic databases (PubMed, EMBASE, Scopus, and Cochrane Library) were searched
for reports up to July 30, 2018. We included all published or unpublished randomized
controlled trials (RCTs). The primary outcome was pain reduction, and the secondary
outcome was the improvement of maximal mouth opening. Weighted mean differences were
utilized for random-effect meta-analysis.
Results
Five RCTs were enrolled in the meta-analysis, comparing PRP injection to placebo (hyaluronic
acid [HA] injection, saline injection, or no injection). The results revealed that
PRP injection was more effective than placebo in pain reduction, but no in the improvement
of maximal mouth opening, in the long term. In the subgroup analysis, PRP injection
yielded better outcome only in pain reduction comparing to HA injection (Weighted
mean difference 1.34, 95% confidence interval [CI] 0.95–1.73).
Conclusions
This meta-analysis demonstrated that PRP injection provided adjuvant efficacy to arthrocentesis
or arthroscopy in pain reduction for temporomandibular joint osteoarthritis in the
long term. Furthermore, PRP injection significantly reduced pain better compared with
HA injection, saline injection, or no injection.
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Article info
Publication history
Published online: November 15, 2018
Accepted:
September 10,
2018
Received:
August 20,
2018
Identification
Copyright
© 2018 Elsevier Inc. All rights reserved.
