Advertisement

The use of radiation therapy in the definitive management of ameloblastic carcinoma: a case report

Published:October 04, 2018DOI:https://doi.org/10.1016/j.oooo.2018.09.009
      Although rare, ameloblastic carcinoma (AC) is one of the most common malignant tumors occurring in the odontogenic epithelium. Evidenced-based medical guidelines for AC are not established because AC is a rare type of cancer. However, surgery for AC is the primary initial treatment modality. A few reports suggest that radiotherapy (RTx) is effective for AC; however, the tumor is generally considered to be radioresistant. Furthermore, if RTx is performed for AC, osteonecrosis may occur because most of the ACs arise from the jaw. Here, we report a case of an older patient with maxillary AC who had underlying medical problems and who received conventional RTx with good outcomes. Ten years after the treatment, no major adverse event accompanying irradiation, local recurrence, or metastasis was observed. We discuss the therapeutic effect and usefulness of RTx on AC. As indicated by our findings, RTx for AC may represent a definitive treatment strategy for patients with poor general conditions or those with tumors that cannot be resected completely.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      References

        • El-Naggar A.K.
        • Chan J.K.C.
        • Grandis J.R.
        • Takata T.
        • Slootweg P.J.
        ed 4. WHO Classification of Head and Neck Tumours. 9. IARC Press, Lyon, France2017: 286-291
        • Karakida K.
        • Aoki T.
        • Sakamoto H.
        • et al.
        Ameloblastic carcinoma, secondary type: a case report.
        Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010; 110: E33-E37
        • Li J.
        • Du H.
        • Li P.
        • Zhang J.
        • Tian W.
        • Tang W.
        Ameloblastic carcinoma: an analysis of 12 cases with a review of the literature.
        Oncol Lett. 2014; 8: 914-920
        • Benlyazid A.
        • Lacroix-Triki M.
        • Aziza R.
        • Gomez-Brouchet A.
        • Guichard M.
        • Sarini J.
        Ameloblastic carcinoma of the maxilla: case report and review of the literature.
        Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007; 104: E17-E24
        • Kruse A.L.
        • Zwahlen R.A.
        • Grätz K.W.
        New classification of maxillary ameloblastic carcinoma based on an evidence-based literature review over the last 60 years.
        Head Neck Oncol. 2009; 1: 31
        • Hall J.M.
        • Weathers D.R.
        • Unni K.K.
        Ameloblastic carcinoma: an analysis of 14 cases.
        Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007; 103: 799-807
        • Saluja T.S.
        • Hosalkar R.
        Reconnoitre ameloblastic carcinoma: a prognostic update.
        Oral Oncol. 2018; 77: 118-124
        • Kennedy W.R.
        • Werning J.W.
        • Kaye F.J.
        • Mendenhall W.M.
        Treatment of ameloblastoma and ameloblastic carcinoma with radiotherapy.
        Eur Arch Otorhinolaryngol. 2016; 273: 3293-3297
        • Avon S.L.
        • McComb J.
        • Clokie C.
        Ameloblastic carcinoma: case report and literature review.
        J Can Dent Assoc. 2003; 69: 573-576
        • Uzawa N.
        • Suzuki M.
        • Miura C.
        • Tomomatsu N.
        • Izumo T.
        • Harada K.
        Primary ameloblastic carcinoma of the maxilla: a case report and literature review.
        Oncol Lett. 2015; 9: 459-467
        • Goldhirsch A.
        • Wood W.C.
        • Coates A.S.
        • Gelber R.D.
        • Thürlimann B.
        • Senn H.J.
        Strategies for subtypes—dealing with the diversity of breast cancer: highlights of the St. Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2011.
        Ann Oncol. 2011; 22: 1736-1747
        • Ishibashi N.
        • Maebayashi T.
        • Aizawa T.
        • Sakaguchi M.
        • Nishimaki H.
        • Masuda S.
        Correlation between the Ki-67 proliferation index and response to radiation therapy in small cell lung cancer.
        Radiat Oncol. 2017; 12: 16
        • Angiero F.
        • Borloni R.
        • Macchi M.
        • Stefani M.
        Ameloblastic carcinoma of the maxillary sinus.
        Anticancer Res. 2008; 28: 3847-3854
        • Bologna-Molina R.
        • Mosqueda-Taylor A.
        • Lopez-Corella E.
        • et al.
        Comparative expression of syndecan-1 and Ki-67 in peripheral and desmoplastic ameloblastomas and ameloblastic carcinoma.
        Pathol Int. 2009; 59: 229-233
        • Casaroto A.R.
        • Toledo G.L.
        • Filho J.L.
        • Soares C.T.
        • Capelari M.M.
        • Lara V.S.
        Ameloblastic carcinoma, primary type: case report, immunohistochemical analysis and literature review.
        Anticancer Res. 2012; 32: 1515-1525
        • Gardner D.G.
        • Pecak A.M.
        The treatment of ameloblastoma based on pathologic and anatomic principles.
        Cancer. 1980; 46: 2514-2519
        • Gardner D.G.
        Radiotherapy in the treatment of ameloblastoma.
        Int J Oral Maxillofac Surg. 1988; 17: 201-205
        • Jensen A.D.
        • Ecker S.
        • Ellerbrock M.
        • Nikoghosyan A.
        • Debus J.
        • Münter M.W.
        Carbon ion therapy for ameloblastic carcinoma.
        Radiat Oncol. 2011; 6: 13
        • Perera E.
        • Lindquist C.
        • Hughes C.
        • Thomas S.
        The use of Gamma Knife stereotactic radiosurgery in the treatment of ameloblastic carcinoma.
        Int J Oral Maxillofac Surg. 2013; 42: 934-938
        • Koca T.
        • Başaran H.
        • Arslan D.
        • et al.
        Prominent response with helical tomotherapy in recurrent ameloblastic carcinoma of maxillary sinus: a case report.
        Radiat Oncol. 2014; 9: 157
        • Takahashi Y.
        • Bandoh N.
        • Miyamoto A.
        • Kamada H.
        Single-fraction helical tomotherapy for ameloblastic carcinoma.
        J Oral Maxillofac Surg. 2016; 74: 302-306
        • Gall J.A.
        • Sartiano G.P.
        • Shreiner D.P.
        Ameloblastoma of the mandible with pulmonary metastasis.
        Oncology. 1975; 32: 118-126
        • Ramadas K.
        • Jose C.C.
        • Subhashini J.
        • Chandi S.M.
        • Viswanathan F.R.
        Pulmonary metastases from ameloblastoma of the mandible treated with cisplatin, adriamycin, and cyclophosphamide.
        Cancer. 1990; 66: 1475-1479
        • Campbell D.
        • Jeffrey R.R.
        • Wallis F.
        • Hulks G.
        • Kerr K.M.
        Metastatic pulmonary ameloblastoma. An unusual case.
        Br J Oral Maxillofac Surg. 2003; 41: 194-196
        • Amzerin M.
        • Fadoukhair Z.
        • Belbaraka R.
        • et al.
        Metastatic ameloblastoma responding to combination chemotherapy: case report and review of the literature.
        J Med Case Rep. 2011; 5: 491
        • Kurppa K.J.
        • Catón J.
        • Morgan P.R.
        • et al.
        High frequency of BRAF V600 E mutations in ameloblastoma.
        J Pathol. 2014; 232: 492-498
        • Brown N.A.
        • Rolland D.
        • McHugh J.B.
        • et al.
        Activating FGFR2-RAS-BRAF mutations in ameloblastoma.
        Clin Cancer Res. 2014; 20: 5517-5526
        • Kaye F.J.
        • Ivey A.M.
        • Drane W.E.
        • Mendenhall W.M.
        • Allan R.W.
        Clinical and radiographic response with combined BRAF-targeted therapy in stage 4 ameloblastoma.
        J Natl Cancer Inst. 2014; 107: 378