Objective
Osteonecrosis of the jaw (ONJ) is commonly associated with antiresorptive therapy.
There have been numerous reports of ONJ unrelated to antiresorptive therapy (ONJuat), confounding risk assessment. This study aimed to determine if ONJuat is associated with one or more particular comorbidities.
Study Design
This was a retrospective case-control study of patients with ONJuat and delayed healing (DH). Each case was matched for patient age and gender, as well
as location of ONJuat or DH lesion to a control patient who had a history of dentoalveolar surgery with
uneventful healing and no history of antiresorptive therapy. Comorbidity data included
medical conditions and smoking.
Results
Of the 92 patients identified, 67 (73%) met the criteria for ONJuat and 25 (27%) for DH. The most common trigger for ONJ and DH was extraction (50%).
The presence of any comorbidity (i.e., at least 1) was more prevalent in ONJuat than among controls (P = .04), and there were more comorbidities in patients with ONJuat and DH than in controls [M(SD) = 1.94 (1.2) and 2.0 (1.3) vs 1.26 (0.89); both P < .001].
Conclusions
ONJ and DH are not limited to patients with a history of antiresorptive therapy. More
comorbidities may signal increased risk for ONJuat and DH.
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Article info
Publication history
Published online: October 05, 2018
Accepted:
September 23,
2018
Received in revised form:
August 23,
2018
Received:
June 13,
2018
Identification
Copyright
© 2018 Elsevier Inc. All rights reserved.
