Objective
The aim of this study was to unveil the reciprocal relation of tumor characteristics
and inflammation in inflammatory myofibroblastic tumor in the head and neck.
Study Design
The study included a retrospective cohort of patients with inflammatory myofibroblastic
tumors treated between 2005 and 2017 in a tertiary hospital. Tumor features and inflammation
were assessed through the expression of anaplastic lymphoma kinase (ALK), the degree
of inflammation and cyclooxygenase-2 (COX-2) expression. The prognostic factors were
analyzed for overall survival (OS) and disease-free survival (DFS) in univariate and
multivariate analyses.
Results
Forty-one patients diagnosed with inflammatory myofibroblastic tumors were followed
up, and 41 paraffin sections were obtained. The positive rate of ALK expression was
21 (51.2%) of 41 patients. Nineteen patients had high-grade ALK expression, and 22
patients had low-grade ALK expression. Thirty-nine patients had high-grade inflammation,
and 2 had low-grade inflammation. The positive rate of COX-2 expression was 100%.
Tumors with both high-grade ALK expression and inflammation had worse DFS (P = .015). The multivariate Cox analysis showed that the grades of ALK expression and
inflammation (P = .004) were independent risk factors for DFS.
Conclusions
Because of the latent synergistic effects of ALK and inflammation in the tumorigenesis
of inflammatory myofibroblastic tumor, the combined therapy of ALK and COX-2 inhibitors
shows promise.
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Article info
Publication history
Published online: May 12, 2020
Accepted:
February 8,
2020
Received in revised form:
January 26,
2020
Received:
October 10,
2019
Identification
Copyright
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