Objectives
One of the treatment goals for osteonecrotic lesions of the jaw, such as medication-related
osteonecrosis of the jaw (MRONJ) or osteoradionecrosis (ORN), is restoration of quality
of life (QOL). This study aimed to identify symptoms that negatively affect QOL in
patients with unhealed MRONJ or ORN.
Study Design
This cross-sectional study included patients who were previously diagnosed with MRONJ
or ORN and who underwent treatment at the Kobe University Hospital between June 2015
and February 2016. Patient QOL was measured by using the Oral Health Impact Profile
(OHIP-14). The predictor variable was disease status (stage and healing). The outcome
variable was OHIP-14. One-way analysis of variance and Tukey’s test were performed.
Results
The study included 74 patients (37 men and 37 women; mean age 70 years). Although
there was no significant difference between the OHIP-14 scores of unhealed MRONJ and
ORN (stages 1–3) and those of healed ones, the “worsened sense of taste” resulted
in significant differences among stages in patients with unhealed MRONJ (P = .027) and the “painful mouth aching” in patients with unhealed ORN (P = .041).
Conclusions
Worsened sense of taste and pain negatively affected QOL in patients with unhealed
MRONJ and ORN.
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Article info
Publication history
Published online: May 31, 2020
Accepted:
March 31,
2020
Received in revised form:
March 4,
2020
Received:
January 7,
2020
Identification
Copyright
© 2020 Elsevier Inc. All rights reserved.
