Objectives
Oral and maxillofacial tumors involving the skull base (SB) are rare and complex,
making treatment difficult and controversial. The purpose of the present study was
to evaluate the treatment efficacy of craniofacial surgery (CFS).
Study Design
Patients who underwent CFS for these tumors between May 2000 and November 2017 were
retrospectively analyzed. Clinicopathologic and treatment modality data were collected
and follow-up was recorded. Kaplan-Meier and log-rank tests and Cox-regression model
were used for survival analysis.
Results
In total, 126 patients were enrolled (70 males and 56 females; 97 malignant tumors).
Squamous cell carcinoma accounted for the majority of tumors. The lip–submandibular–neck
approach was most frequently applied. Through-and-through SB bone or partial dura
resection was performed in 42 cases. A pathologic positive margin was found in 18
cases. Of the included patients, 80 underwent simultaneous craniofacial reconstruction.
The postoperative complications rate was 11.1%. Estimated 1-year, 3-year, and 5-year
overall survival rates were 78.8%, 68.2%, and 54.4% respectively; and the 1-year,
3-year, and 5-year recurrence-free survival rates were 77.4%, 66.8%, and 63.8%, respectively.
Multivariate analysis indicated postoperative complications, radiotherapy, recurrence,
and metastasis status had a negative impact on survival (P < .05).
Conclusions
Although tumors involving the SB had various clinicopathologic characteristics, with
interdisciplinary cooperation, CFS is an optimal option.
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Article info
Publication history
Published online: July 15, 2020
Accepted:
June 5,
2020
Received in revised form:
May 4,
2020
Received:
February 22,
2019
Identification
Copyright
© 2020 Elsevier Inc. All rights reserved.
