Advertisement
Original Article| Volume 130, ISSUE 5, P603-608, November 2020

Evaluation of mercury release from dental amalgam after cone beam computed tomography and magnetic resonance imaging with 3.0-T and 1.5-T magnetic field strengths

Published:August 07, 2020DOI:https://doi.org/10.1016/j.oooo.2020.07.009

      Objectives

      This in vitro study aimed to investigate leakage of mercury from amalgam restorations after cone beam computed tomography (CBCT) and magnetic resonance imaging (MRI) examinations.

      Study Design

      In total, 238 amalgam disks were prepared and placed in saline solution. The samples were allocated randomly to 7 groups, with 34 samples in each group. CBCT imaging was performed for 4 groups with different imaging parameters (narrow/wide field of view [FOV]; standard/high-resolution). MRI procedures were performed with 3.0-T and 1.5-T magnetic field strengths. No imaging was performed for the samples in the control group. The amalgam samples were removed from the tubes 24 hours after imaging and submitted for plasma mass spectrometry analysis. Kruskal-Wallis and Dunn's tests were performed to compare data. A P value less than .05 was accepted as statistically significant.

      Results

      The highest mean mercury value was found in the 3.0-T MRI group, whereas the lowest mean value was found in the narrow FOV, standard-resolution CBCT group. There were no significant differences between the control group and the experimental groups (P ≥ .338) or between the experimental groups (P > .05).

      Conclusions

      CBCT and MRI procedures similar to those used in patient care caused no significantly different mercury release compared with nonexposed samples.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      References

        • Yilmaz S.
        • Adisen M.Z.
        Ex vivo mercury release from dental amalgam after 7.0-T and 1.5-T MRI.
        Radiology. 2018; 288: 799-803
        • Oriso K.
        • Kobayashi T.
        • Sasaki M.
        • et al.
        Impact of the static and radiofrequency magnetic fields produced by a 7 T MR imager on metallic dental materials.
        Magn Reson Med Sci. 2016; 15: 26-33
        • Guzzi G.
        • Minoia C.
        • Pigatto P.D.
        • Severi G.
        Methylmercury, amalgams, and children's health.
        Environ Health Perspect. 2006; 114: A149-A150
        • World Health Organization (WHO): IPCS
        Environmental health criteria 101: Organic mercury.
        WHO, Geneva, Switzerland1990
        • World Health Organization (WHO): IPCS
        Environmental health criteria 118: Inorganic mercury.
        WHO, Geneva, Switzerland1991
        • U.S. Environmental Protection Agency (EPA)
        Mercury, elemental: Reference concentration for chronic inhalation exposure (RfC).
        Integrated Risk Information System. EPA, Washington, DC1995
        • Yip H.K.
        • Li D.K.
        • Yau D.C.
        Dental amalgam and human health.
        Int Dent J. 2003; 53: 464-468
        • Chin G.
        • Chong J.
        • Kluczewska A.
        • Lau A.
        • Gorjy S.
        • Tennant M.
        The environmental effects of dental amalgam.
        Aust Dent J. 2000; 45: 246-249
        • Furhoff A.K.
        • Tomson Y.
        • Ilie M.
        • et al.
        A multidisciplinary clinical study of patients suffering from illness associated with release of mercury from dental restorations. Medical and odontological aspects.
        Scand J Prim Health Care. 1998; 16: 247-252
        • Brune D.
        • Evje D.M.
        Man's mercury loading from a dental amalgam.
        Sci Total Environ. 1985; 44: 51-63
        • Tobi H.
        • Kreulen C.M.
        • Vondeling H.
        • van Amerongen W.E.
        Cost-effectiveness of composite resins and amalgam in the replacement of amalgam Class II restorations.
        Community Dent Oral Epidemiol. 1999; 27: 137-143
        • Soncini A.
        • Maserejian N.
        • Trachtenberg F.
        • Tavares M.
        • Hayes C.
        The longevity of amalgam versus compomer/composite restorations in posterior primary and permanent teeth: findings from the New England Children's Amalgam Trial.
        J Am Dent Assoc. 2007; 138: 763-772
        • Counter S.A.
        • Buchanan L.H.
        Mercury exposure in children: a review.
        Toxicol Appl Pharmacol. 2004; 198: 209-230
        • Clarkson T.W.
        • Magos L.
        • Myers G.J.
        The toxicology of mercury—current exposures and clinical manifestations.
        N Engl J Med. 2003; 349: 1731-1737
        • Homme K.G.
        • Kern J.K.
        • Haley B.E.
        • et al.
        New science challenges old notion that mercury dental amalgam is safe.
        Biometals. 2014; 27: 19-24
        • Müller-Miny H.
        • Erber D.
        • Möller H.
        • Müller-Miny B.
        • Bongartz G.
        Is there a hazard to health by mercury exposure from amalgam due to MRI?.
        J Magn Reson Imaging. 1996; 6: 258-260
        • Kursun S.
        • Oztas B.
        • Atas
        • Tastekin M.
        Effects of x-rays and magnetic resonance imaging on mercury release from dental amalgam into artificial saliva.
        Oral Radiol. 2014; 30: 142-146
        • Ahn H.J.
        • Song K.B.
        • Lee Y.E.
        • et al.
        Surface change of dental amalgam after treatment with 10% carbamide peroxide.
        Dent Mater J. 2006; 25: 303-308
        • Gurgan S.
        • Kiremitci A.
        • Yalcin F.
        • Alpaslan T.
        • Yazici E.
        Effect of carbamide peroxide treatments on the metal-ion release and microstructure of different dental amalgams.
        Oper Dent. 2007; 32: 476-481
        • Shabani M.B.
        • Shiina Y.
        • Kirscht F.G.
        • Shimanuki Y.
        Recent advanced applications of AAS and ICP-MS in the semiconductor industry.
        Mater Sci Eng. 2003; 102: 238-246
        • Nardi E.P.
        • Evangelista F.S.
        • Tormen L.
        • et al.
        The use of inductively coupled plasma mass spectrometry (ICP-MS) for the determination of toxic and essential elements in different types of food samples.
        Food Chem. 2009; 112: 727-732
        • Miksa I.R.
        • Buckley C.L.
        • Carpenter N.P.
        • Poppenga R.H.
        Comparison of selenium determination in liver samples by atomic absorption spectroscopy and inductively coupled plasma–mass spectrometry.
        J Vet Diagn Invest. 2005; 17: 331-340
        • Cortada M.
        • Giner L.
        • Costa S.
        • et al.
        Galvanic corrosion behavior of titanium implants coupled to dental alloys.
        J Mater Sci Mater Med. 2000; 11: 287-293
        • Takada Y.
        • Nakamura K.
        • Kimura K.
        • Okuno O.
        Corrosion behavior of the stainless steel composing dental magnetic attachments.
        Int Cong. 2005; 1284: 314-315
        • Johansson B.I.
        • Bergman B.
        Corrosion of titanium and amalgam couples: effect of fluoride, area size, surface preparation and fabrication procedures.
        Dent Mater. 1995; 11: 41-46
        • Chang J.C.
        • Oshida Y.
        • Gregory R.L.
        • et al.
        Electrochemical study on microbiology-related corrosion of metallic dental materials.
        Biomed Mater Eng. 2003; 13: 281-295
        • Mayer V.R.
        • Diehl W.
        Abgabe von quecksilber aus amalgamfullungen in den speichel.
        Dtsch Zahnarztl Z. 1976; 31: 855-859
        • da Silva Moura W.
        • Chiqueto K.
        • Pithon G.M.
        • et al.
        Factors influencing the effective dose associated with CBCT: a systematic review.
        Clin Oral Investig. 2019; 23: 1319-1330
        • Ludlow J.B.
        • Timothy R.
        • Walker C.
        • et al.
        Effective dose of dental CBCT—a meta-analysis of published data and additional data for nine CBCT units.
        Dentomaxillofac Radiol. 2015; 4420140197
        • Ludlow J.B.
        • Walker C.
        Assessment of phantom dosimetry and image quality of i-CAT FLX cone-beam computed tomography.
        Am J Orthod Dentofacial Orthop. 2013; 144: 802-817
        • Cross R.R.
        • Shapiro M.D.
        • Som P.M.
        MRI of the parapharyngeal space.
        Radiol Clin North Am. 1989; 27: 353-378
        • Nakada T.
        Clinical application of high and ultra-high-field MRI.
        Brain Dev. 2007; 29: 325-335
        • Soher B.J.
        • Dale B.M.
        • Merkle E.M.
        A review of MR physics: 3 T versus 1.5 T.
        Magn Reson Imaging Clin N Am. 2007; 15: 277-290
        • International Commission on Non-Ionizing Radiation Protection
        Guidelines for limiting exposure to time-varying electric, magnetic, and electromagnetic fields (up to 300 GHz).
        Health Phys. 1998; 74: 494-522
        • Theysohn J.M.
        • Maderwald S.
        • Kraff O.
        • et al.
        Subjective acceptance of 7 Tesla MRI for human imaging.
        MAGMA. 2008; 21: 63-72
        • Park S.M.
        • Kamondetdacha R.
        • Amjad A.
        • Nyenhuis J.A.
        MRI safety: RF-induced heating near straight wires.
        IEEE Int Magnet Conf. 2005; 41: 4197-4199
        • Ladd M.E.
        • Bachert P.
        • Meyerspeer M.
        • et al.
        Pros and cons of ultra-high-field MRI/MRS for human application.
        Prog Nucl Magn Reson Spectrosc. 2018; 109: 1-50
        • Bitz A.K.
        • Kraff O.
        • Orzada S.
        • et al.
        Assessment of RF safety of transmit coils at 7 Tesla by experimental and numerical procedures.
        Proc Int Soc Magn Reson Med. 2011; 17: 490