Objective
Identifying markers that influence oral squamous cell carcinoma (OSCC) prognosis is
a fundamental strategy to improve the overall survival of patients. Markers such as
eukaryotic translation elongation factor 1δ (EEF1D), fascin, N-terminal propeptide
of type I collagen (PINP), and cancer-associated fibroblasts (CAFs) have been noticed
in OSCCs and their levels are closely related to the prognosis of tumors. Our aim
was to confirm the role of those markers in OSCC prognosis.
Study Design
Immunohistochemistry was performed in 90 OSCC specimens. The associations between
clinicopathologic features and expression of markers were assessed by χ2 test. Kaplan-Meier curves and univariate and multivariate Cox regression models were
used for survival analysis. Markers were analyzed individually and in combination.
Results
High expression of EEF1D (P = .017) and PINP (P = .02) and abundant density of CAFs in tumor stroma (P = .005) predicted significantly poor survival in OSCC patients. Multivariate analysis
revealed that all 3 parameters are individually independent prognostic factors of
OSCC patients, and their combination improved the discrimination of patients at high
risk for poor survival.
Conclusions
Our results suggested that the expression of EEF1D and PINP and the density of CAFs
might influence the survival of patients with OSCC.
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Article info
Publication history
Published online: October 29, 2020
Accepted:
September 7,
2020
Received in revised form:
August 6,
2020
Received:
March 26,
2020
Identification
Copyright
© 2020 Published by Elsevier Inc.
