A 60-year-old male patient came to the oral medicine clinic for evaluation of his nonhealing oral sores, which had persisted for 12 months. He complained of painful tongue ulcers that affected his ability to eat and contributed to a 35-pound weight loss over the last 5 months. The patient reported fatigue in the last 3 months, accompanied by a 5-week history of skin abnormalities. He also had a brief history of a scrotal lesion in the past. The patient had been evaluated and treated by multiple providers throughout the past year without positive outcomes. His primary care physician (PCP) had initially prescribed magic mouthwash and acyclovir to manage the oral ulcers. Three months previously, the patient's general dentist had referred him to an oral surgeon for a biopsy of the tongue lesions, which were diagnosed by a general pathologist as “ulceration with reactive changes and dense mixed inflammatory infiltrate.” Additional treatment included a dexamethasone rinse that the patient only used briefly because it exacerbated his oral pain.
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- Clopidogrel induced oral ulceration.Ir Med J. 2005; 98: 282
- Statins and oral ulceration.Br Dent J. 2016; 220: 45-46
- Comparative risk of oral ulcerations among antipsychotics users – population-based retrospective cohort study.Pharmacoepidemiol Drug Saf. 2016; 25: 123-132
- Adverse drug events in the oral cavity.Dermatol Clin. 2020; 38: 523-533
- World Workshop on Oral Medicine VI: A systematic review of the treatment of mucocutaneous pemphigus vulgaris.Oral Surg Oral Med Oral Pathol Oral Radiol. 2015; 120 (132-142.e161)
- Paraneoplastic pemphigus: a short review.Clin Cosmet Investig Dermatol. 2016; 9: 291-295
- Paraneoplastic pemphigus.Australas J Dermatol. 2013; 54: 241-250
- Orofacial manifestations and dental management of systemic lupus erythematosus: A review.Oral Dis. 2021; 27: 151-167
- Oral manifestations of systemic lupus erythematosus patients in Qatar: a pilot study.Int J Rheumatol. 2018; 20186052326
- The global changing pattern of the oral manifestations of HIV.Oral Dis. 2020; 26: 22-27
- Oral manifestations of sexually transmitted diseases.Clin Dermatol. 2004; 22: 520-527
- Antinuclear antibodies in infectious diseases.Infect Dis (Lond). 2020; 52: 177-185
- Syphilis: the renaissance of an old disease with oral implications.Head Neck Pathol. 2009; 3: 195-206
- Oral findings in secondary syphilis.Med Oral Patol Oral Cir Bucal. 2018; 23: e138-e143
- Oral syphilis: a reemerging infection prompting clinicians’ alertness.Case Rep Dent. 2016; 20166295920
- The modern epidemic of syphilis.N Engl J Med. 2020; 382: 845-854
- Oral ulcers as a presentation of secondary syphilis.Clin Exp Dermatol. 2018; 43: 868-875
- Sexually acquired syphilis: historical aspects, microbiology, epidemiology, and clinical manifestations.J Am Acad Dermatol. 2020; 82: 1-14
Centers for Disease Control and Prevention. Syphilis (Treponema pallidum): 2018 case definition. Available at: https://wwwn.cdc.gov/nndss/conditions/syphilis/case-definition/2018/. Accessed January 31, 2021.
- N Engl J Med. 2019; 381: 1358-1363
- Association of HIV preexposure prophylaxis with incidence of sexually transmitted infections among individuals at high risk of HIV infection.JAMA. 2019; 321: 1380-1390
- Perceived advantages and disadvantages of using pre-exposure prophylaxis (PrEP) among sexually active black women: an exploratory study.J Black Sex Relatsh. 2016; 3: 1-24
Published online: March 31, 2021
Accepted: March 19, 2021
Received in revised form: March 12, 2021
Received: December 18, 2020
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