Advertisement

Osteosarcoma of the jaws: Report of 3 cases with emphasis on the early clinical and radiographic signs

Published:September 11, 2021DOI:https://doi.org/10.1016/j.oooo.2021.09.001
      Osteosarcoma is the most common primary malignancy of the jaws and is treated by radical surgical resection. Early detection is crucial because removing the lesion with clean margins contributes most to the outcome. We present 3 cases of osteosarcoma occurring in the interradicular region of the mandible, 2 of which were thought to represent nonmalignant processes upon initial presentation. All 3 demonstrated early but significant clinical and radiographic features indicative of the malignant disease process. Radiographically, these cases had in common unilateral periodontal ligament (PDL) space widening, displacement of teeth, and growth of the crestal bone. Clinically, all 3 cases presented with a painless intraoral swelling. Case 1: a 20-year-old African American man presented with swelling and loose teeth with a duration of 1.5 months. Histopathologic diagnosis of osteoblastic osteosarcoma, high grade, was made. Case 2: a 75-year-old White man presented with a 2 × 2 cm expansile lesion with a duration of 2 months. Histopathologic diagnosis of chondroblastic osteosarcoma was made. Case 3: a 63-year-old White woman presented with a 5- to 6-mm lesion with a duration of at least 1 month. Histopathologic diagnosis of chondroblastic osteosarcoma was made. All 3 cases were treated with wide surgical resection.
      To read this article in full you will need to make a payment

      References

        • Lindsey BA
        • Markel JE
        • Kleinerman ES.
        Osteosarcoma Overview.
        Rheumatol Ther. 2017; 4: 25-43
        • Bertin H
        • Gomez-Brouchet A
        • Rédini F.
        Osteosarcoma of the jaws: an overview of the pathophysiological mechanisms.
        Crit Rev Oncol Hematol. 2020; 156103126
        • Paparella ML
        • Olvi LG
        • Brandizzi D
        • Keszler A
        • Santini-Araujo E
        • Cabrini RL.
        Osteosarcoma of the jaw: an analysis of a series of 74 cases.
        Histopathology. 2013; 63: 551-557
        • Bennett JH
        • Thomas G
        • Evans AW
        • Speight PM.
        Osteosarcoma of the jaws: a 30-year retrospective review.
        Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2000; 90: 323-333
        • Ogunlewe MO
        • Ajayi OF
        • Adeyemo WL
        • Ladeinde AL
        • James O.
        Osteogenic sarcoma of the jaw bones: a single institution experience over a 21-year period.
        Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006; 101: 76-81
        • Fernandes R
        • Nikitakis NG
        • Pazoki A
        • Ord RA.
        Osteogenic Sarcoma of the Jaw: a 10-Year Experience.
        J Oral Maxillofac Surg. 2007; 65: 1286-1291
      1. WHO Classification of Tumours Editorial Board.
        5th ed. WHO Classification of Tumours of Soft Tissue and Bone. 3. IARC Press, Lyon, France2020
        • Malik F
        • Gleysteen JP
        • Agarwal S.
        Osteosarcoma of the jaw: report of 3 cases (including the rare epithelioid variant) with review of literature.
        Oral Surg Oral Med Oral Pathol Oral Radiol. 2021; 131: e71-e80
        • Buchanan A
        • Kalathingal S
        • Capes J
        • Kurago Z.
        Unusual presentation of extranodal diffuse large B-cell lymphoma in the head and neck: description of a case with emphasis on radiographic features and review of the literature.
        Dentomaxillofac Radiol. 2015; 4420140288
        • Garrington GE
        • Scofield HH
        • Cornyn J
        • Hooker SP.
        Osteosarcoma of the jaws. Analysis of 56 cases.
        Cancer. 1967; 20: 377-391
        • Lee RJ
        • Arshi A
        • Schwartz HC
        • Christensen RE.
        Characteristics and prognostic factors of osteosarcoma of the jaws: a retrospective cohort study.
        JAMA Otolaryngol Head Neck Surg. 2015; 141: 470-477
        • ElKordy MA
        • ElBaradie TS
        • ElSebai HI
        • KhairAlla SM
        • Amin AAE.
        Osteosarcoma of the jaw: challenges in the diagnosis and treatment.
        J Egypt Natl Canc Inst. 2018; 30: 7-11
        • Demicco EG
        • Deshpande V
        • Nielsen GP
        • Kattapuram SV
        • Rosenberg AE.
        Well-differentiated osteosarcoma of the jaw bones: a clinicopathologic study of 15 cases.
        Am J Surg Pathol. 2010; 34: 1647-1655
        • Baumhoer D
        • Brunner P
        • Eppenberger-Castori S
        • Smida J
        • Nathrath M
        • Jundt G.
        Osteosarcomas of the jaws differ from their peripheral counterparts and require a distinct treatment approach. Experiences from the DOESAK Registry.
        Oral Oncol. 2014; 50: 147-153
        • Granowski-LeCornu M
        • Chuang S-K
        • Kaban LB
        • August M.
        Osteosarcoma of the jaws: factors influencing prognosis.
        J Oral Maxillofac Surg. 2011; 69: 2368-2375
        • Mardinger O
        • Givol N
        • Talmi YP
        • Taicher S.
        Osteosarcoma of the jaw. The Chaim Sheba Medical Center experience.
        Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2001; 91: 445-451
        • Doval DC
        • Kumar RV
        • Kannan V
        • et al.
        Osteosarcoma of the jaw bones.
        Br J Oral Maxillofac Surg. 1997; 35: 357-362
        • Ginat D
        • Schulte J
        • Gooi Z
        • Cipriani N.
        High-grade conventional osteosarcoma of the mandible associated with P53 germline mutation.
        J Craniofac Surg. 2018; 29: 738-740
        • Mamachan P
        • Dang V
        • Bharadwaj NS
        • DeSilva N
        • Kant P.
        Chondroblastic osteosarcoma—A case report and review of literature.
        Clin Case Rep. 2019; 8: 2097-2102