Peripheral ameloblastic fibro-odontoma—Report of 2 cases of a very rare entity

Published:September 19, 2021DOI:
      Ameloblastic fibro-odontoma (AFO) is a rare benign mixed odontogenic tumor that affects children and young adults. AFO occurs mainly intraosseous. Extraosseous AFO is extremely rare. We report 2 cases of rare peripheral ameloblastic fibro-odontoma in 2- and 12-year-old female patients. Microscopic examination revealed a benign proliferation of odontogenic epithelium associated with a dentinoid material distributed within a cell-rich mesenchymal stroma resembling dental papilla. Simple surgical excision of the lesion is usually curative. There was no recurrence after a short period of follow-up. Clinicians should be cognizant of this rare entity, which can be considered in a differential diagnosis of gingival growths that are noted in early childhood.
      To read this article in full you will need to make a payment


      1. Barnes L, Eveson JW, Reichart P, Sidransky D. Odontogenic Tumors. In: World Health Organization Classification of Tumours: Pathology and Genetics of Head and Neck Tumours. Vol 9. 3rd ed. IARC Publications; 2005:309.

        • Cohen DM
        • Bhattacharyya I.
        Ameloblastic fibroma, ameloblastic fibro-odontoma, and odontoma.
        Oral Maxillofac Surg Clin North Am. 2004; 16: 375-384
        • Augello M
        • Rabufetti A
        • Ghazal G
        • Yurtsever H
        • Leiggener C.
        Ameloblastic fibro-odontoma in children. Clinical aspects and review of the literature.
        Oral Maxillofac Surg Cases. 2017; 3: 34-41
        • Ide F
        • Mishima K
        • Saito I
        • Kusama K.
        Rare peripheral odontogenic tumors: report of 5 cases and comprehensive review of the literature.
        Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008; 106: e22-e28
        • Lin YC
        • Hsu HM
        • Liu CS
        • Yuan K.
        A peripheral ameloblastic fibro-odontoma in a 3-year-old girl: case report, immunohistochemical analysis, and literature review.
        Case Rep Dent. 2014; 2014321671
        • Reibel J
        • Grønbaek AB
        • Poulsen S.
        Peripheral ameloblastic fibro-odontoma or peripheral developing complex odontoma: report of a case.
        Int J Paediatr Dent. 2011; 21: 468-470
        • Atarbashi Moghadam S
        • Mokhtari S
        Peripheral developing odontoma or peripheral ameloblastic fibroodontoma: a rare challenging case.
        Case Rep Dent. 2016; 20169379017
        • Ritwik P
        • Brannon RB.
        Peripheral odontogenic fibroma: a clinicopathologic study of 151 cases and review of the literature with special emphasis on recurrence.
        Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010; 110: 357-363