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Evaluated expression of CELSR3 in oral squamous cell carcinoma is associated with perineural invasion and poor prognosis

  • Author Footnotes
    a These authors contribute equally to this study.
    Ke Zheng
    Footnotes
    a These authors contribute equally to this study.
    Affiliations
    Department of Pathology, The First Affiliated Hospital of Fujian Medical University, 20 Chazhong Road, Fuzhou, 350005, China
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  • Author Footnotes
    a These authors contribute equally to this study.
    Ting Lan
    Footnotes
    a These authors contribute equally to this study.
    Affiliations
    Fujian Key Laboratory of Oral Diseases, Fujian Biological Materials Engineering and Technology Center of Stomatology, School and Hospital of Stomatology, Fujian Medical University, 88 Jiaotong Road, Fuzhou, 350004, China
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  • Guo-ping Li
    Affiliations
    Department of Pathology, The First Affiliated Hospital of Fujian Medical University, 20 Chazhong Road, Fuzhou, 350005, China
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  • Li Huang
    Affiliations
    Department of Dentistry, The First Affiliated Hospital of Fujian Medical University, 20 Chazhong Road, Fuzhou, 350005, China
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  • Yu-peng Chen
    Affiliations
    Department of Pathology, The First Affiliated Hospital of Fujian Medical University, 20 Chazhong Road, Fuzhou, 350005, China
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  • Bo-Hua Su
    Affiliations
    Fujian Key Laboratory of Oral Diseases, Fujian Biological Materials Engineering and Technology Center of Stomatology, School and Hospital of Stomatology, Fujian Medical University, 88 Jiaotong Road, Fuzhou, 350004, China

    Department of Preventive Dentistry, School and Hospital of Stomatology, Fujian, Medical University, 246 Yangqiao Middle Road, Fuzhou 350000, China
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  • Sheng Zhang
    Correspondence
    Sheng Zhang. M.D, Department of Pathology, The First Affiliated Hospital of Fujian Medical University, 20 Chazhong Road, Fuzhou, 350005, China
    Affiliations
    Department of Pathology, The First Affiliated Hospital of Fujian Medical University, 20 Chazhong Road, Fuzhou, 350005, China
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  • Da-Li Zheng
    Correspondence
    Corresponding authors: Da-Li Zheng. Ph.D, Key laboratory of Stomatology of Fujian Province, School and Hospital of Stomatology, Fujian Medical University, 88 Jiao Tong Road, Fuzhou 350004, China
    Affiliations
    Fujian Key Laboratory of Oral Diseases, Fujian Biological Materials Engineering and Technology Center of Stomatology, School and Hospital of Stomatology, Fujian Medical University, 88 Jiaotong Road, Fuzhou, 350004, China
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  • Author Footnotes
    a These authors contribute equally to this study.
Published:October 29, 2021DOI:https://doi.org/10.1016/j.oooo.2021.10.016

      Abstract

      Objective

      : The objective of this study was to evaluate CELSR3 expression and explore its potential mechanism in oral squamous cell carcinoma.

      Study design

      : CELSR3 mRNA expression was analyzed using The Cancer Genome Atlas (TCGA) database. CELSR3 protein expression in 135 surgical oral squamous cell carcinoma specimens was observed by immunohistochemical staining. Staining results were used to investigate association between CELSR3 expression and clinicopathological characteristics and prognosis. Bioinformatics analyses were used to explore the potential mechanism of CELSR3 in head and neck squamous cell carcinoma.

      Results

      : CELSR3 mRNA expression was upregulated in patients with head and neck squamous cell carcinoma in the TCGA-HNSC dataset. Increased CELSR3 protein expression was associated with perineural invasion and poor clinical outcomes in oral squamous cell carcinoma patients. Bioinformatics analyses revealed that CELSR3 is involvement in axonogenesis, neuron migration and cell-cell adhesion, all of which are involved in the process of perineural invasion.

      Conclusion

      : CELSR3 may play a pro-oncogenic role in oral squamous cell carcinoma and can predict perineural invasion and poor survival. CELSR3 may be involved in oral squamous cell carcinoma progression by modulating perineural invasion.

      Keywords

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