Objective
The aim of this study was to measure the association between antihypertensive medication
use and mandibular cortical thickness.
Study Design
This retrospective cross-sectional study was comprised of a study sample of 169 patients
aged 40 to 69. Cone beam computed tomography scans were examined. The buccal cortical
thickness of the mandibular ramus was measured. Participants were separated into the
control or study group based on use of antihypertensive medications. The predictor
variable was the use of antihypertensive medications. The primary outcome variable
was cortical thickness of the mandible. Age was identified as a covariate affecting
the outcome variable. The data was analyzed with a one-way analysis of covariance
(ANCOVA) to remove the effect of age on the outcome variable. The groups were subdivided
based on the sex of the patient.
Results
The study sample was composed of 169 patients with a mean age of 52.1, and 54% were
female. There were 67 patients in the antihypertensive group (39.6%). A mean difference
of 0.21 mm was found (P = .0010, 95% CI 0.09, 0.34 mm). The difference persisted after adjusting for age
with one-way ANCOVA testing (P < .001).
Conclusions
This study suggests that there may be an association between antihypertensive use
and mandibular cortical thickness. Age may be an effect modifier with the effect increasing
in older patients.
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Article info
Publication history
Published online: April 04, 2022
Accepted:
March 29,
2022
Received in revised form:
March 26,
2022
Received:
January 4,
2022
Identification
Copyright
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