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First cases of oligodontia as a manifestation of the Zika virus congenital syndrome

  • Carla Cristina Gonçalves da Costa
    Correspondence
    Corresponding author: Carla Cristina Gonçalves da Costa,
    Affiliations
    Primary Health Care Program, State University of Montes Claros, Unimontes, Montes Claros, Minas Gerais, Brazil
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  • Verônica Oliveira Dias
    Affiliations
    Primary Health Care Program, State University of Montes Claros, Unimontes, Montes Claros, Minas Gerais, Brazil

    Pediatric Dentistry, Dental School, State University of Montes Claros, Unimontes, Montes Claros, Minas Gerais, Brazil
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  • Daniella Reis Barbosa Martelli
    Affiliations
    Primary Health Care Program, State University of Montes Claros, Unimontes, Montes Claros, Minas Gerais, Brazil

    Semiology Clinic, Dental School, State University of Montes Claros, Unimontes, Montes Claros, Minas Gerais, Brazil
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  • Nádia Carolina Teixeira Marques
    Affiliations
    Center for Rehabilitation of Craniofacial Anomalies, Dental School, University of Alfenas, Alfenas, Minas Gerais, Brazil
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  • Ricardo D. Coletta
    Affiliations
    Department of Oral Diagnosis, State University of Campinas, FOP-UNICAMP, Piracicaba, São Paulo, Brazil

    Graduate Program in Oral Biology, School of Dentistry, University of Campinas, Piracicaba, São Paulo, Brazil
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  • Hercílio Martelli Júnior
    Affiliations
    Primary Health Care Program, State University of Montes Claros, Unimontes, Montes Claros, Minas Gerais, Brazil

    Center for Rehabilitation of Craniofacial Anomalies, Dental School, University of Alfenas, Alfenas, Minas Gerais, Brazil

    Oral Medicine, Dental School, State University of Montes Claros, Unimontes, Montes Claros, Minas Gerais, Brazil
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Published:April 23, 2022DOI:https://doi.org/10.1016/j.oooo.2022.04.045

      Objective

      The aim of this study was to characterize the oral alterations in patients with the congenital syndrome caused by Zika virus infection (CZS).

      Study Design

      Ten children with CZS from the Association of Mothers of Microcephaly, Montes Claros, Minas Gerais State, Brazil were included. Data collection consisted of an interview with the parents, intraoral examination, and panoramic radiography.

      Results

      Oligodontia was found in 2 children. The first child, a 3-year-old boy, had 12 dental absences (2 primary maxillary lateral incisors, 2 primary mandibular lateral incisors, 2 primary maxillary canines, 1 primary mandibular canine, 1 primary maxillary first molar, 2 primary mandibular second molars, and 2 primary maxillary second molars), and the second child, a 5-year-old boy, showed 15 missing teeth (4 primary central incisors, 1 primary maxillary lateral incisor right, 2 primary mandibular lateral incisors, 2 primary maxillary canines, 1 primary mandibular canine, 1 primary mandibular first molar, and 4 primary second molars).

      Conclusions

      This study is the first report of oligodontia in Brazilian patients with CZS. Further studies with CZS patients are needed to better understand the occurrence and the association between Zika virus and oligodontia.

      Abbreviations:

      ZIKV (Zika virus), CZV (Zika virus congenital syndrome), CMV (Cytomegalovirus), TOURCH (toxoplasmosis, other, rubella, cytomegalovirus, herpes infections.), RT-PCR (Reverse transcription polymerase chain reaction)
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      References

        • Aguiar YPC
        • Alencar CRB
        • Cavalcanti SALB
        • Cavalcanti AFC
        • Melo ASO
        • Cavalcanti AL.
        Chronology of the first deciduous tooth eruption in brazilian children with microcephaly associated with zika virus: a longitudinal study.
        Pesqui Bras Odontopediatria Clin Integr. 2018; 18: 3982
        • Alencar PNB
        • Lima M
        • Carvalho IF
        • et al.
        Radiographic evaluation of dental anomalies in patients with congenital Zika virus syndrome.
        Braz Oral Res. 2021; 35: e043
        • de Araújo TVB
        • Rodrigues LC
        • de Alencar Ximenes RA
        • et al.
        Association between Zika virus infection and microcephaly in Brazil, January to May, 2016: preliminary report of a case-control study.
        Lancet Infect Dis. 2016; 16: 1356-1363
        • Barbosa MHM
        • Magalhães-Barbosa MC
        • Robaina JR
        • Prata-Barbosa A
        • Lima MAMT
        • Cunha AJLAD.
        Auditory findings associated with Zika virus infection: an integrative review.
        Braz J Otorhinolaryngol. 2019; 85: 642-663
        • Carvalho IF
        • Alencar PNB
        • Carvalho de Andrade MD
        • et al.
        Clinical and x-ray oral evaluation in patients with congenital Zika Virus.
        J Appl Oral Sci. 2019; 27e20180276
        • Cavalcanti AL
        • de Arruda TD
        • Fernandes LHF
        • et al.
        Use of medicines by infants with microcephaly caused by congenital zika virus infection and implications to oral health.
        Pesqui Bras Odontopediatria Clín Integr. 2020; 20: e5565
        • Cota ALS
        • Lopes MGM
        • Pio IM
        • de Oliveira MJ
        • Rodrigues DF
        • Panjwan C.
        Oral findings in children with congenital Zika syndrome: a case series.
        Saude e Pesqui. 2020; 13: 133-142
        • D'Agostino ÉS
        • Chagas JRLP
        • Cangussu MCT
        • Vianna MIP.
        Chronology and sequence of deciduous teeth eruption in children with microcephaly associated to the Zika virus.
        Spec Care Dentist. 2020; 40: 3-9
        • da Silva Sobrinho AR
        • Ramos LFS
        • Maciel YL
        • et al.
        Orofacial features in children with microcephaly associated with Zika virus: A scoping review.
        Oral Dis. 2022; 28: 1022-1028
        • Fonteles CSR
        • Marques Ribeiro E
        • Sales Aragão Santos M
        • et al.
        Lingual frenulum phenotypes in Brazilian infants with congenital zika syndrome.
        Cleft Palate Craniofac J. 2018; 55: 1391-1398
        • Fournier BP
        • Bruneau MH
        • Toupenay S
        • et al.
        Patterns of dental agenesis highlight the nature of the causative mutated genes.
        J Dent Res. 2018; 97: 1306-1316
        • Gogia A
        • Kakar A.
        Zika virus infection in pregnant women in Rio de Janeiro.
        Curr Med Res Pract. 2016; 6: 95
        • Gonçalves TM
        • Gonçalves LM
        • Sabino-Bezerra JR
        • Santos-Silva AR
        • da Silva WJ
        • Garcia RC.
        Multidisciplinary therapy of extensive oligodontia: a case report.
        Braz Dent J. 2013; 24: 174-178
        • Gusmão TPL
        • Faria ABS
        • Leão Filho JC
        • Carvalho AAT
        • Gueiros LAM
        • Leão JC
        Dental changes in children with congenital Zika syndrome.
        Oral Dis. 2020; 26: 457-464
        • Leite CN
        • Varellis MLZ.
        Microcefalia and the Brazilian dentistry.
        J Health NPEPS. 2016; 1: 297-304
        • Mora-Salamanca AF
        • Porras-Ramírez A
        • Restrepo FPH.
        Burden of disease due to microcephaly associated with the Zika virus in Colombia.
        Cad Saúde Pública. 2020; 36e00215319
        • Musso D
        • Ko AI
        • Baud D.
        Zika virus infection—after the pandemic.
        N Engl J Med. 2019; 381: 1444-1457
        • de Oliveira AMM
        • de Melo EGM
        • Mendes MLT
        • et al.
        Oral and maxillofacial conditions, dietary aspects, and nutritional status of children with congenital Zika syndrome.
        Oral Surg Oral Med Oral Pathol Oral Radiol. 2020; 130: 71-77
        • Pacheco O
        • Beltrán M
        • Nelson CA
        • et al.
        Zika virus disease in Colombia—preliminary report.
        N Engl J Med. 2020; 383: e44
        • Park H
        • Song JS
        • Shin TJ
        • Hyun HK
        • Kim YJ
        • Kim JW.
        WNT10A mutations causing oligodontia.
        Arch Oral Biol. 2019; 103: 8-11
        • Pio MI
        • de Oliveira MJ
        • Cota ALS.
        Evaluation of the dental caries experience in children with congenital Zika syndrome.
        Oral Surg Oral Med Oral Pathol Oral Radiol. 2020; 130: e276
        • Raziee L
        • Judd P
        • Carmichael R
        • Chen S
        • Sidhu N
        • Suri S.
        Impacts of oligodontia on oral health-related quality of life reported by affected children and their parents.
        Eur J Orthod. 2020; 42: 250-256
        • Silva MCPMD
        • Arnaud MA
        • Lyra MCA
        • et al.
        Dental development in children born to Zikv-infected mothers: a case-based study.
        Arch Oral Biol. 2020; 110104598
        • Siqueira RMP
        • Santos MTBR
        • Cabral GMP.
        Alterations in the primary teeth of children with microcephaly in Northeast Brazil: a comparative study.
        Int J Paediatr Dent. 2018; 28: 523-532
        • Teixeira GA
        • Dantas DNA
        • Carvalho GAFL
        • Silva AND
        • Lira ALBC
        • Enders BC.
        Análise do conceito síndrome congênita pelo Zika virus [in Portuguese].
        Cien Saude Colet. 2020; 25: 567-574https://doi.org/10.1590/1413-81232020252.30002017

      Further Reading

        • Cavalcanti AFC
        • Aguiar Y
        • de Oliveira Melo AS
        • de Freitas Leal J
        • Cavalcanti AL
        • Cavalcanti S.
        Teething symptoms in children with congenital Zika syndrome: a 2-year follow-up.
        Int J Paediatr Dent. 2019; 29: 74-78
        • Santos GPG
        • Gouveia MTO
        • Costa RMPG
        • Santos AMRD
        • Avelino FVSD.
        Effects in the development of children exposed to zika virus in the fetal period: An integrative review.
        Rev Bras Enferm. 2020; 73e20190883