Objective
Rhinocerebral mucormycosis (RCM) is the most common variant and the presenting features
in the head and neck region are seldom pathognomonic. The aim of this systematic review
was to obtain a thorough insight into the predisposing factors, clinical features,
disease course, management protocol, outcome, and prognosis.
Study Design
An electronic search was carried out using MEDLINE by PubMed, Scopus, Google Scholar,
Web of Science, and EMBASE databases. Articles in which the clinical findings on the
extra- and intraoral features of RCM were included for systematic review. Descriptive
statistics was applied to obtain the results.
Results
A total of 124 case studies (90 case reports, 34 case series) which yielded 219 patients.
Diabetes mellitus (57.40%) was the most common comorbid condition. Neurologic manifestations
were noted in 23.3% of the individuals. Maxillary/hard palate involvement was a common
occurrence (59.2%). Intra-oral necrotic lesions with eschar were noted in 75/219 patients.
Amphotericin B was the commonly used drug for the management, and surgical debridement
was performed in majority of the cases. The mortality rate was 18.4%.
Conclusions
The clinical manifestations often mimic odontogenic symptoms, hence a sound knowledge
about the pathogenesis and course of the disease will aid in the prompt diagnosis
and management.
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Article info
Publication history
Published online: June 17, 2022
Accepted:
June 11,
2022
Received in revised form:
June 3,
2022
Received:
May 9,
2022
Footnotes
Mathangi Kumar and Ragavi Alagarsamy contributed equally to the work.
Identification
Copyright
© 2022 Elsevier Inc. All rights reserved.
