Objective
The aim of this study was to investigate the available evidence on the efficacy of
lycopene in the management of oral potentially malignant disorders (OPMDs).
Study Design
PubMed, Scopus, Web of Science, Google Scholar, China National Knowledge Infrastructure,
and ProQuest databases were searched up to April 20, 2022. All clinical trials that
assessed the efficacy of lycopene (I) on the signs/symptoms (O) of patients with OPMDs
(P) in comparison to either active control or placebo (C) were included. Meta-analysis
was conducted using the RevMan software (Cochrane Collaboration, London, UK).
Results
A total of 27 clinical trials (20 on oral submucosa fibrosis [OSF], 5 on oral lichen
planus [OLP], and 2 on leukoplakia) were included. Overall, lycopene was efficacious
in reducing signs and symptoms of OSF, OLP, and leukoplakia. The pooled data revealed
comparable efficacy of lycopene and prednisolone in reducing pain and promoting clinical
resolution of OLP. Additionally, the pooled data reported comparable efficacy of lycopene
and conventional controls in improving the mouth opening and tongue protrusion in
patients with OSF.
Conclusions
The results reveal promising effects of lycopene in alleviating signs and symptoms
of OSF, OLP, and leukoplakia. However, owing to the observed heterogeneity and short
follow-up periods, further well-designed studies with long-term therapy and follow-up
are highly recommended.
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Article info
Publication history
Published online: August 20, 2022
Accepted:
August 13,
2022
Received in revised form:
July 21,
2022
Received:
June 23,
2022
Identification
Copyright
© 2022 Elsevier Inc. All rights reserved.
