A Pigmented Nodule in the Buccal Mucosa

Published:August 21, 2022DOI:
      A 59-year-old woman presented with a chief complaint of a 1-year history of a slow-growing painless nodule in the left buccal mucosa. She had no past or familial history of head and neck diseases, although she reported regular tobacco and alcohol consumption. She denied taking any medication at the time of the consultation. Physical examination was unremarkable, but an intraoral examination revealed a submucous nodule located in close relation to the occlusal line of the left buccal mucosa near the mandibular residual roots. The lesion was mobile and firm but slightly compressible on palpation. Clinically, the lesion presented as a well-defined asymptomatic pigmented nodule covered by intact mucosa, measuring approximately 8 mm (Figure 1).
      Fig 1
      Fig. 1Clinical presentation evidencing a well-defined asymptomatic pigmented nodule in the buccal mucosa.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


        • Gondak RO
        • da Silva-Jorge R
        • Jorge J
        • Lopes MA
        • Vargas PA
        Oral pigmented lesions: clinicopathologic features and review of the literature.
        Med Oral Patol Oral Cir Bucal. 2012; 17: e919-e924
        • Meleti M
        • Mooi WJ
        • Casparie MK
        • van der Waal I.
        Melanocytic nevi of the oral mucosa - no evidence of increased risk for oral malignant melanoma: an analysis of 119 cases.
        Oral Oncol. 2007; 43: 976-981
        • Re Cecconi D
        • Achilli A
        • Tarozzi M
        • et al.
        Mucoceles of the oral cavity: a large case series (1994-2008) and a literature review.
        Med Oral Patol Oral Cir Bucal. 2010; 15: e551-e556
        • Choi YJ
        • Byun JS
        • Choi JK
        • Jung JK.
        Identification of predictive variables for the recurrence of oral mucocele.
        Med Oral Patol Oral Cir Bucal. 2019; 24: e231-e235
        • Ribeiro JL
        • Moraes RM
        • Carvalho BFC
        • Nascimento AO
        • Milhan NVM
        • Anbinder AL.
        Oral pyogenic granuloma: an 18-year retrospective clinicopathological and immunohistochemical study.
        J Cutan Pathol. 2021; 48: 863-869
        • Gordón-Núñez MA
        • de Vasconcelos Carvalho M
        • Benevenuto TG
        • Lopes MF
        • Silva LM
        • Galvão HC.
        Oral pyogenic granuloma: a retrospective analysis of 293 cases in a Brazilian population.
        J Oral Maxillofac Surg. 2010; 68: 2185-2188
        • Ramakrishnan K
        • Palanivel I
        • Narayanan V
        • Chandran S
        • Gurram P.
        Management of vascular malformations in the oral and maxillofacial region: a systematic review.
        J Stomatol Oral Maxillofac Surg. 2021; 122: 588-599
        • Buckmiller LM
        • Richter GT
        • Suen JY.
        Diagnosis and management of hemangiomas and vascular malformations of the head and neck.
        Oral Dis. 2010; 16: 405-418
        • Pérez-de-Oliveira ME
        • Wagner VP
        • Araújo ALD
        • et al.
        Prognostic value of CRTC1-MAML2 translocation in salivary mucoepidermoid carcinoma: systematic review and meta-analysis.
        J Oral Pathol Med. 2020; 49: 386-394
        • Fonseca FP
        • Sena Filho M
        • Altemani A
        • Speight PM
        • Vargas PA
        Molecular signature of salivary gland tumors: potential use as diagnostic and prognostic marker.
        J Oral Pathol Med. 2016; 45: 101-110
        • Liyanage RL
        • Wadusinghearachchi NS
        • Siriwardena BS
        • Jayasooriya PR
        • Tilakaratne WM.
        Pigmented mucoepidermoid carcinoma with spindle cell differentiation.
        Oral Surg Oral Med Oral Pathol Oral Radiol. 2014; 117: e449-e451
        • González-Arriagada WA
        • Santos-Silva AR
        • Ito FA
        • Vargas PA
        • Lopes MA.
        Calcifications may be a frequent finding in mucoepidermoid carcinomas of the salivary glands: a clinicopathologic study.
        Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011; 111: 482-485
        • Mariz BALA
        • do Socorro Queiroz
        • Feio P
        • Roza ALOC
        • et al.
        Clinical predictors of malignancy in palatal salivary gland tumors.
        Oral Dis. 2019; 25: 1919-1924
        • Oide T
        • Hiroshima K
        • Takahashi Y
        • et al.
        Mucoepidermoid carcinoma with extensive spindled morphology and melanocytic marker expression.
        Hum Pathol. 2017; 67: 181-186
        • Thomas KM
        • Hutt MS
        • Borgstein J.
        Salivary gland tumors in Malawi.
        Cancer. 1980; 46: 2328-2334
        • Takeda Y
        • Kurose A.
        Pigmented mucoepidermoid carcinoma, a case report and review of the literature on melanin-pigmented salivary gland tumors.
        J Oral Sci. 2006; 48: 253-256
        • Marucci G
        • Marchetti C
        • Betts CM
        • Foschini MP.
        Pigmented mucoepidermoid carcinoma of the oral cavity: a case report.
        Int J Surg Pathol. 2005; 13: 295-297
        • Aufdemorte TB
        • Van Sickels JE
        • Glass BJ.
        Melanin pigmentation in a mucoepidermoid tumor of a minor salivary gland.
        J Oral Maxillofac Surg. 1985; 43: 876-879
        • Kubiak J
        • Fantasia J
        • Li JY.
        Pigmented mucoepidermoid carcinoma: a case report.
        Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2019; 128: e74-e75
        • Takeda Y
        • Kurose A.
        Pigmented mucoepidermoid carcinoma, a case report and review of the literature on melanin-pigmented salivary gland tumors.
        J Oral Sci. 2006; 48: 253-256
        • Sekine J
        • Anami M
        • Fujita S
        • Vieth M
        • Inokuchi T.
        A case of mucoepidermoid carcinoma with melanin pigmentation manifested in the palate.
        Virchows Arch. 2005; 446: 460-462