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N-MID, P1NP, β-CTX, and phosphorus in adolescents with condylar resorption

  • Dahe Zhang
    Affiliations
    Department of Oral Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China

    College of Stomatology, Shanghai Jiao Tong University, Shanghai, PR China

    National Center for Stomatology, Shanghai, PR China

    National Clinical Research Center for Oral Diseases, Shanghai, PR China

    Shanghai Key Laboratory of Stomatology, Shanghai, PR China
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  • Bian Wang
    Affiliations
    College of Stomatology, Shanghai Jiao Tong University, Shanghai, PR China

    National Center for Stomatology, Shanghai, PR China

    National Clinical Research Center for Oral Diseases, Shanghai, PR China

    Shanghai Key Laboratory of Stomatology, Shanghai, PR China

    Department of Assisted Reproduction, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China
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  • Xuzhou Sun
    Affiliations
    College of Stomatology, Shanghai Jiao Tong University, Shanghai, PR China

    National Center for Stomatology, Shanghai, PR China

    National Clinical Research Center for Oral Diseases, Shanghai, PR China

    Shanghai Key Laboratory of Stomatology, Shanghai, PR China

    Department of Orthopedics, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China
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  • Pei Shen
    Affiliations
    Department of Oral Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China

    College of Stomatology, Shanghai Jiao Tong University, Shanghai, PR China

    National Center for Stomatology, Shanghai, PR China

    National Clinical Research Center for Oral Diseases, Shanghai, PR China

    Shanghai Key Laboratory of Stomatology, Shanghai, PR China
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  • Jing Ge
    Affiliations
    Department of Oral Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China

    College of Stomatology, Shanghai Jiao Tong University, Shanghai, PR China

    National Center for Stomatology, Shanghai, PR China

    National Clinical Research Center for Oral Diseases, Shanghai, PR China

    Shanghai Key Laboratory of Stomatology, Shanghai, PR China
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  • Zhigui Ma
    Correspondence
    Corresponding author.
    Affiliations
    Department of Oral Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China

    College of Stomatology, Shanghai Jiao Tong University, Shanghai, PR China

    National Center for Stomatology, Shanghai, PR China

    National Clinical Research Center for Oral Diseases, Shanghai, PR China

    Shanghai Key Laboratory of Stomatology, Shanghai, PR China
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  • Chi Yang
    Correspondence
    Corresponding author.
    Affiliations
    Department of Oral Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China

    College of Stomatology, Shanghai Jiao Tong University, Shanghai, PR China

    National Center for Stomatology, Shanghai, PR China

    National Clinical Research Center for Oral Diseases, Shanghai, PR China

    Shanghai Key Laboratory of Stomatology, Shanghai, PR China
    Search for articles by this author
Published:September 23, 2022DOI:https://doi.org/10.1016/j.oooo.2022.09.010

      Objective

      Condylar resorption (CR) is a temporomandibular joint disease that causes various physical or functional defects. We aimed to find the association between CR and bone metabolism levels.

      Study Design

      In this study, we recruited patients visiting the Orthodontic Clinic at Shanghai Ninth People's Hospital from January 2020 to September 2021. Patient characteristics, magnetic resonance imaging examination results, bone mineral density (BMD), Z-score, bone turnover markers, minerals, and hormones were collected and analyzed.

      Results

      The 89 participants were divided into CR (n = 46) and normal (n = 43) groups. Univariate logistic regression showed that N-terminal mid-fragment of osteocalcin (N-MID), procollagen type 1 N-terminal propeptide (P1NP), β-C-terminal telopeptide of type 1 collagen (β-CTX), and phosphorus (P < .001 for all) were protective factors, and BMD (P = .047) was a risk factor for CR. Multivariable logistic regression showed that N-MID, P1NP, β-CTX, and phosphorus (odds ratio <1, P < .05 for all) were protective factors for CR. Receiver operating characteristic curves showed these indicators to effectively predict CR occurrence (area under the curve >0.7; P < .001).

      Conclusion

      Adolescents with low serum N-MID, P1NP, β-CTX, and phosphorus levels were associated with a higher risk of CR. We suggest that these indicators can guide clinicians in the early detection and prevention of CR in adolescents.
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