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N-MID, P1NP, β-CTX, and phosphorus in adolescents with condylar resorption

  • Dahe Zhang
    Affiliations
    Department of Oral Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine; College of Stomatology, Shanghai Jiao Tong University; National Center for Stomatology; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology
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  • Bian Wang
    Affiliations
    Department of Assisted Reproduction, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine; College of Stomatology, Shanghai Jiao Tong University; National Center for Stomatology; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology
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  • Xuzhou Sun
    Affiliations
    Department of Orthopedics, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine; College of Stomatology, Shanghai Jiao Tong University; National Center for Stomatology; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology
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  • Pei Shen
    Affiliations
    Department of Oral Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine; College of Stomatology, Shanghai Jiao Tong University; National Center for Stomatology; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology
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  • Jing Ge
    Affiliations
    Department of Oral Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine; College of Stomatology, Shanghai Jiao Tong University; National Center for Stomatology; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology
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  • Zhigui Ma
    Correspondence
    Corresponding Authors: Chi Yang, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, No. 639, Zhi-zao-ju Road, Shanghai 200011, P.R. China
    Affiliations
    Department of Oral Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine; College of Stomatology, Shanghai Jiao Tong University; National Center for Stomatology; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology
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  • Chi Yang
    Correspondence
    Corresponding Authors: Zhigui Ma, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, No. 639, Zhi-zao-ju Road, Shanghai 200011, P.R. China
    Affiliations
    Department of Oral Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine; College of Stomatology, Shanghai Jiao Tong University; National Center for Stomatology; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology
    Search for articles by this author
Published:September 23, 2022DOI:https://doi.org/10.1016/j.oooo.2022.09.010

      Abstract

      Objective

      Condylar resorption (CR) is a temporomandibular joint (TMJ) disease that causes various physical or functional defects. We aimed to find the association between CR and bone metabolism levels.

      Study design

      In this study, we recruited patients visiting the Orthodontic Clinic at Shanghai Ninth People's Hospital from January 2020 to September 2021. Patient characteristics, MRI examination results, bone mineral density (BMD), Z-score, bone turnover markers, minerals and hormones were collected and analyzed.

      Results

      The 89 participants were divided into CR (n = 46) and Normal (n = 43) groups. Univariate logistic regression showed that N-terminal mid-fragment of osteocalcin (N-MID), procollagen type 1 N-terminal propeptide (P1NP), β-C-terminal telopeptide of type 1 collagen (β-CTX), and phosphorus (P < 0.001 for all) were protective factors, and BMD (P = 0.047) was a risk factor for CR. Multivariable logistic regression showed that N-MID, P1NP, β-CTX and phosphorus (OR < 1, P < 0.05 for all) were protective factors for CR. Receiver operating characteristic curves showed these indicators to effectively predict CR occurrence (area under the curve > 0.7; P < 0.001).

      Conclusion

      Adolescents with low serum N-MID, P1NP, β-CTX, and phosphorus levels were associated with a higher risk of CR. We suggest that these indicators can guide clinicians in the early detection and prevention of CR in adolescents.

      Keywords

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