Objective
Condylar resorption (CR) is a temporomandibular joint disease that causes various
physical or functional defects. We aimed to find the association between CR and bone
metabolism levels.
Study Design
In this study, we recruited patients visiting the Orthodontic Clinic at Shanghai Ninth
People's Hospital from January 2020 to September 2021. Patient characteristics, magnetic
resonance imaging examination results, bone mineral density (BMD), Z-score, bone turnover markers, minerals, and hormones were collected and analyzed.
Results
The 89 participants were divided into CR (n = 46) and normal (n = 43) groups. Univariate logistic regression showed that N-terminal mid-fragment
of osteocalcin (N-MID), procollagen type 1 N-terminal propeptide (P1NP), β-C-terminal
telopeptide of type 1 collagen (β-CTX), and phosphorus (P < .001 for all) were protective factors, and BMD (P = .047) was a risk factor for CR. Multivariable logistic regression showed that N-MID,
P1NP, β-CTX, and phosphorus (odds ratio <1, P < .05 for all) were protective factors for CR. Receiver operating characteristic
curves showed these indicators to effectively predict CR occurrence (area under the
curve >0.7; P < .001).
Conclusion
Adolescents with low serum N-MID, P1NP, β-CTX, and phosphorus levels were associated
with a higher risk of CR. We suggest that these indicators can guide clinicians in
the early detection and prevention of CR in adolescents.
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Article info
Publication history
Published online: September 23, 2022
Accepted:
September 19,
2022
Received in revised form:
September 2,
2022
Received:
May 31,
2022
Publication stage
In Press Journal Pre-ProofIdentification
Copyright
© 2022 Elsevier Inc. All rights reserved.
