Condylar resorption (CR) is a temporomandibular joint (TMJ) disease that causes various
physical or functional defects. We aimed to find the association between CR and bone
In this study, we recruited patients visiting the Orthodontic Clinic at Shanghai Ninth
People's Hospital from January 2020 to September 2021. Patient characteristics, MRI
examination results, bone mineral density (BMD), Z-score, bone turnover markers, minerals
and hormones were collected and analyzed.
The 89 participants were divided into CR (n = 46) and Normal (n = 43) groups. Univariate logistic regression showed that N-terminal mid-fragment
of osteocalcin (N-MID), procollagen type 1 N-terminal propeptide (P1NP), β-C-terminal
telopeptide of type 1 collagen (β-CTX), and phosphorus (P < 0.001 for all) were protective factors, and BMD (P = 0.047) was a risk factor for CR. Multivariable logistic regression showed that
N-MID, P1NP, β-CTX and phosphorus (OR < 1, P < 0.05 for all) were protective factors for CR. Receiver operating characteristic
curves showed these indicators to effectively predict CR occurrence (area under the
curve > 0.7; P < 0.001).
Adolescents with low serum N-MID, P1NP, β-CTX, and phosphorus levels were associated
with a higher risk of CR. We suggest that these indicators can guide clinicians in
the early detection and prevention of CR in adolescents.