Objective
The aim of this study was to evaluate and compare quality of life (QoL) parameters
in patients with oral potential malignant disorders (OPMDs), namely, oral lichen planus
(OLP) and oral epithelial dysplasia (OED).
Study Design
A cross-sectional study was completed at the oral maxillofacial surgery/oral medicine
practices at University of Pennsylvania. Patients with clinical and histopathologic
confirmation of OLP or OED from January to June 2021 were included in the study. The
primary predictor variable was the OPMD type. The primary outcome variable was the
score of 3 separate surveys: the Chronic Oral Mucosal Disease Questionnaire-26 (COMDQ-26),
Oral Potential Malignant Disorder QoL Questionnaire (OPMDQoL), and Hospital Anxiety
and Depression Scale. Multiple linear regression was used to determine independent
predictors of increased/decreased questionnaire scores.
Results
The final study sample consisted of 100 patients:53 patients had OLP (53.0%), 39 patients
had OED (39.0%), and 8 patients had OLP with OED (8.0%). Relative to OED, OLP added
15.7 points to the COMDQ-26 survey score (P < .001). Relative to OED, OLP added 8.9 points to the OPMDQoL survey score (P = .003).
Conclusions
Oral lichen planus shows significantly poorer QoL specifically within the COMD-26
and OPMDQoL questionnaires, compared with OED. Additionally, patients with OPMDs aged
40 to 64 years were independently associated with higher COMD-26 scores compared with
older patients (>65 years).
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Oral Surgery, Oral Medicine, Oral Pathology and Oral RadiologyAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
REFERENCES
NIH. National Cancer Institute. Available at: https://seer.cancer.gov/statfacts/html/oralcav.html. Accessed April 15, 2022.
- Qualitative analysis of the impact of oral potentially malignant disorders on daily life activities.PLoS One. 2017; 12e0175531
- Dyskeratosis congenita.Mayo Clin Proc. 2019; 94: 1668-1669
- Oral epithelial dysplasia: classifications and clinical relevance in risk assessment of oral potentially malignant disorders.J Oral Maxillofac Pathol. 2019; 23: 19-27
- Oral lichen planus and lichenoid mucositis.Dent Clin North Am. 2014; 58: 299-313
- Update on oral epithelial dysplasia and progression to cancer.Head Neck Pathol. 2007; 1: 61-66
- Potentially malignant disorders of the oral cavity and oral dysplasia: a systematic review and meta-analysis of malignant transformation rate by subtype.Head Neck. 2020; 42: 539-555
- Diagnosis of oral lichen planus: a position paper of the American Academy of Oral and Maxillofacial Pathology.Oral Surg Oral Med Oral Pathol Oral Radiol. 2016; 122: 332-354
- The clinical features, malignant potential, and systemic associations of oral lichen planus: a study of 723 patients.J Am Acad Dermatol. 2002; 46: 207-214
- Quality of life in patients with oral potentially malignant disorders: a systematic review.Oral Surg Oral Med Oral Pathol Oral Radiol. 2015; 119: 644-655
- Web-based information on oral dysplasia and precancer of the mouth—quality and readability.Oral Oncol. 2018; 82: 69-74
- Relevance of psychosocial factors to quality of life in oral cancer and oral lichen planus: a prospective comparative study.Br J Oral Maxillofac Surg. 2015; 53: 621-626
- Impact of oral potentially malignant disorders on quality of life.J Oral Pathol Med. 2018; 47: 60-65
- Oral lichen planus (OLP): clinical and complementary diagnosis.An Bras Dermatol. 2010; 85: 669-675
- Quality of life in patients with oral lichen planus.J Eval Clin Pract. 2010; 16: 111-113
- Health-related quality of life and its associated predictors in patients with oral lichen planus: a cross-sectional study.Int Dent J. 2020; 71: 140-152
- Severity of oral lichen planus and oral lichenoid lesions is associated with anxiety.Clin Oral Investig. 2019; 23: 4441-4448
- Oral health-related quality of life of patients with oral lichen planus, oral leukoplakia, or oral squamous cell carcinoma.J Oral Maxillofac Surg. 2014; 72: 1517-1522
- Sociodemographic risk indicators for depressive symptoms among persons with oral cancer or oral epithelial dysplasia.J Oral Maxillofac Surg. 2005; 63: 513-520
- Oral health-related quality of life in different clinical forms of oral lichen planus.Clin Oral Investig. 2020; 24: 301-308
- Psychological disorders and oral lichen planus: matched case-control study and literature review.Oral Dis. 2016; 22: 226-234
- Psychological disorders and quality of life in oral lichen planus patients and a control group.Oral Dis. 2019; 25: 1645-1651
- Emotional assessment of patients with oral lichen planus.Int J Dermatol. 2015; 54: 29-32
- Smoking and drinking in relation to depressive symptoms among persons with oral cancer or oral epithelial dysplasia.Head Neck. 2010; 32: 578-587
- Betel quid, smoking and alcohol dependency among patients with oral potentially malignant disorders and oral cancer in Sri Lanka; a preliminary case-control study.Asian Pac J Cancer Biol. 2021; 6: 207
- Surgical management of oral and mucosal dysplasias: the case for laser excision.J Oral Maxillofac Surg. 2007; 65: 293-295
Article info
Publication history
Published online: November 16, 2022
Accepted:
November 8,
2022
Received in revised form:
November 1,
2022
Received:
August 15,
2022
Identification
Copyright
© 2022 Published by Elsevier Inc.
