Quality of life in patients with oral potentialLY malignant disorders: Oral lichen planus and oral epithelial dysplasia

Published:November 16, 2022DOI:



      The aim of this study was to evaluate and compare quality of life (QoL) parameters in patients with oral potential malignant disorders (OPMD), namely oral lichen planus (OLP) and oral epithelial dysplasia (OED).

      Study Design

      A cross-sectional study was completed at the oral maxillofacial surgery/oral medicine practices at University of Pennsylvania. Patients with clinical and histopathological confirmation of OLP or OED from January-June 2021 were included in the study. The primary predictor variable was the OPMD type. The primary outcome variable was the score of three separate surveys: Chronic Oral Mucosal Disease Questionnaire-26 (COMDQ-26), Oral Potential Malignant Disorder QoL Questionnaire (OPMDQoL), and Hospital Anxiety and Depression Scale (HADs). Multiple linear regression was used to determine independent predictors of increased/decreased questionnaire scores.


      The final study sample consisted of 100 patients, of whom 53 patients had OLP (53.0%), 39 patients had OED (39.0%), and eight patients had OLP with OED (8.0%). Relative to OED, OLP added 15.7 points to the COMD-26 survey score (p < 0.001). Relative to OED, OLP added 8.9 points to the OPMDQoL survey score (p = 0.003).


      OLP shows significantly poorer QoL specifically within the COMD-26 and OPMDQoL questionnaires, compared to OED. Additionally, Patients with OPMDs aged 40-64 years were independently associated with higher COMD-26 scores compared to elderly patients (>65 years).
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Stoopler ET, Shanti RM. Dyskeratosis Congenita. Mayo Clin Proc. 2019;94(9):1668-1669.