Case Report| Volume 135, ISSUE 5, e102-e107, May 2023

Download started.


Oral involvement of cutaneous T-cell lymphoma: A rare entity

Published:December 22, 2022DOI:
      Mycosis fungoides (MF) is a rare cutaneous T-cell lymphoma (CTCL) with significant morbidity and mortality rates. Involvement of MF in the oral cavity is uncommon, often follows cutaneous involvement, and is usually associated with a poor prognosis. Herein, we describe a case of a 72-year-old White male with biopsy-proven oral T-cell lymphoma (TCL) in the setting of MF with systemic disease progression. Mycosis fungoides with oral involvement can often prove challenging to diagnose and manage. Thorough medical history intake and clinical examination supported by histopathologic and immunohistochemical analysis are imperative because delay in the diagnosis can lead to disease progression.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


        • Larocca C
        • Kupper T.
        Mycosis fungoides and Sézary syndrome: an update.
        Hematol Oncol Clin North Am. 2019; 33: 103-120
        • Goyal A
        • Goyal K
        • Carter JB
        • et al.
        Mycosis fungoides.
        in: Carter JB Goyal A Duncan LM Atlas of Cutaneous Lymphomas: Classification and Differential Diagnosis. 1st ed. Springer Science+Business Media, Berlin, Germany2015: 139-152
        • Kaufman AE
        • Patel K
        • Goyal K
        • et al.
        Mycosis fungoides: developments in incidence, treatment and survival.
        J Eur Acad Dermatol Venereol. 2020; 34: 2288-2294
        • Goodly J
        • Calonje E.
        Cutaneous lymphoproliferative diseases and related disorders.
        in: Calonje E Brenn T Lazar A Billings SD McKee's Pathology of the Skin: With Clinical Correlations. 5th ed. Elsevier, Edinburgh, Scotland2020: 1403-1519
        • Feldman AM
        • Sevak P
        • McHargue C
        • Lim HW
        • Siddiqui F.
        Mycosis fungoides involving head and neck mucosal sites: review of the literature.
        Appl Rad Onco. 2017; 6: 11-19
        • Sultan AS
        • Mostoufi B
        • Papadimitriou JC
        • Koka R
        • Basile J
        • Younis RH.
        Large cell transformation of oral mycosis fungoides.
        Head Neck Pathol. 2018; 12: 247-251
        • Neville B
        • Damm DD
        • Allen C
        • Chi A
        Oral and Maxillofacial Pathology.
        Saunders, Philadelphia, PA2009
        • Schoenfeld J
        • Accetta J.
        Oral involvement of cutaneous T-cell lymphoma.
        Dermatol Online J. 2017; 23 (13030/qt1xn9q4n9)
        • Sirois DA
        • Miller AS
        • Harwick RD
        • Vonderheid EC
        Oral manifestations of cutaneous T-cell lymphoma. A report of eight cases. Oral Surg Oral Med Oral.
        Pathol. 1993; 75: 700-705
        • Epstein JB
        • Epstein JD
        • Le ND
        • Gorsky M.
        Characteristics of oral and paraoral malignant lymphoma: a population-based review of 361 cases.
        Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2001; 92: 519-525
        • Jacobs C
        • Hoppe RT.
        Non-Hodgkin’s lymphomas of head and neck extranodal sites.
        Int J Radiat Oncol Biol Phys. 1985; 11: 357-364
        • Silva TD
        • Ferreira CB
        • Leite GB
        • de Menezes Pontes JR
        • Antunes HS.
        Oral manifestations of lymphoma: a systematic review.
        Ecancermedicalscience. 2016; 10: 665
        • Jabbari Azad F
        • Delavarian Z
        • Hatami M
        • Rahimi H
        • Abdolvahed MR
        Extranodal NK/T cell lymphoma with destruction of the uvulae: a case report.
        Iran J Otorhinolaryngol. 2017; 29: 101-108
        • Chua MS
        • Veness MJ.
        Mycosis fungoides involving the oral cavity.
        Australas Radiol. 2002; 46: 336-339
        • Raychaudhury T.
        Management strategies for mycosis fungoides in India.
        Indian J Dermatol. 2017; 62: 137-141
        • Scarisbrick JJ.
        Survival in mycosis fungoides and Sezary syndrome: how can we predict outcome?.
        J Invest Dermatol. 2020; 140: 281-283