Objective
The aim of this study was to identify the prevalence of orofacial alterations in sickle-cell
disease (SCD) and to compare it with the general population.
Study design
This review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses
2020 guidelines. The search was conducted on PubMed, Embase, Scientific Electronic
Library Online, Web of Science, Cochrane Library, gray literature, and references
of the included articles.
Results
A total of 770 records were found, and 28 studies were selected. In SCD, the prevalence
of decreased bone density was 57% (95% CI: 35%-80%), with Q: P < .01 and I2 = 95%; for stepladder pattern was 30% (IC: 13%-47%), Q: P < .01 and I²: 93%; for delayed eruption was 20% (95% CI: 6%-34%), with Q: P < .01 and I2 = 86, Q: P < .01 and I2 = 99%; and for malocclusion, 66% (95% CI: 39%-92%), Q: P < .01 and I2 = 98%. A high risk of bias was observed in relation to the sample size of the studies.
A limited number of articles compared the prevalence of orofacial alterations in patients
with SCD and healthy individuals.
Conclusions
Decreased bone density, malocclusion, orofacial pain, tooth necrosis, eruption delay,
periodontal disease, and neuropathies may be present in patients with SCD with variable
prevalence.
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Article info
Publication history
Published online: December 26, 2022
Accepted:
December 21,
2022
Received in revised form:
December 18,
2022
Received:
September 16,
2022
Identification
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