Prevalence of orofacial alterations in patients with sickle-cell disease: Systematic review and meta-analysis

Published:December 26, 2022DOI:



      . To identify the prevalence of orofacial alterations in sickle-cell disease (SCD) and to compare it with general population.

      Study design

      . This review followed the PRISMA 2020 guidelines. The search was conducted on PubMed, Embase, SciELO, Web of Science, Cochrane Library, grey literature and references of the included articles.


      . 770 records were found, and 28 studies were selected. In SCD the prevalence of decreased bone density was 57% (95% confidence interval [CI]: 35%–80%), with Q: p < 0.01 and I2 = 95%; for stepladder pattern was 30% (IC:13%-47%), Q: p<0.01 and I²: 93%; for delayed eruption was 20% (95% CI: 6%–34%), with Q: p < 0.01 and I2 = 86, Q: p < 0.01 and I2 = 99%; and for malocclusions, 66% (95% CI: 39%–92%), Q: p < 0.01 and I2 = 98%. A high risk of bias was observed in relation to the sample size of the studies. A limited number of articles compared the prevalence of orofacial alterations in SCD and health patients.


      . Decreased bone density, malocclusion, orofacial pain, tooth necrosis, eruption delay, periodontal disease and neuropathies may be present in SCD patients with variable prevalence.


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