ABSTRACT
Objective
. To identify the prevalence of orofacial alterations in sickle-cell disease (SCD)
and to compare it with general population.
Study design
. This review followed the PRISMA 2020 guidelines. The search was conducted on PubMed,
Embase, SciELO, Web of Science, Cochrane Library, grey literature and references of
the included articles.
Results
. 770 records were found, and 28 studies were selected. In SCD the prevalence of decreased
bone density was 57% (95% confidence interval [CI]: 35%–80%), with Q: p < 0.01 and
I2 = 95%; for stepladder pattern was 30% (IC:13%-47%), Q: p<0.01 and I²: 93%; for delayed
eruption was 20% (95% CI: 6%–34%), with Q: p < 0.01 and I2 = 86, Q: p < 0.01 and I2 = 99%; and for malocclusions, 66% (95% CI: 39%–92%), Q: p < 0.01 and I2 = 98%. A high risk of bias was observed in relation to the sample size of the studies.
A limited number of articles compared the prevalence of orofacial alterations in SCD
and health patients.
Conclusion
. Decreased bone density, malocclusion, orofacial pain, tooth necrosis, eruption delay,
periodontal disease and neuropathies may be present in SCD patients with variable
prevalence.
Keywords
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Article info
Publication history
Accepted:
December 21,
2022
Received in revised form:
December 18,
2022
Received:
September 16,
2022
Publication stage
In Press Journal Pre-ProofIdentification
Copyright
© 2023 Elsevier Inc. All rights reserved.
