Twenty-year analysis of photobiomodulation clinical studies for oral mucositis: a scoping review

Published:December 27, 2022DOI:



      Review the first 20 years in photobiomodulation (PBM) clinical studies for oral mucositis (OM) mitigation.

      Study design

      A scoping review screened controlled clinical studies. PBM devices, protocols, and clinical outcomes were analyzed.


      75 studies met the inclusion criteria. The first study dated from 1992, and the term PBM was first published in 2017. Public services, placebo-controlled randomized trials, and head and neck chemoradiantion patients were predominant among included studies. Prophylactic red intraoral laser protocols were mostly used. Comparing the outcomes of all protocols was unfeasible due to missing treatment parameters and non-homogeneous measurements.


      The main barrier to optimizing clinical protocols of PBM for OM was the lack of standardization in clinical studies. Although PBM use is now globally present in oncology settings and generally marked by good outcomes reported, additional randomized clinical trials with well-described methodologies are necessary.


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