Abstract
Objective
Review the first 20 years in photobiomodulation (PBM) clinical studies for oral mucositis
(OM) mitigation.
Study design
A scoping review screened controlled clinical studies. PBM devices, protocols, and
clinical outcomes were analyzed.
Results
75 studies met the inclusion criteria. The first study dated from 1992, and the term
PBM was first published in 2017. Public services, placebo-controlled randomized trials,
and head and neck chemoradiantion patients were predominant among included studies.
Prophylactic red intraoral laser protocols were mostly used. Comparing the outcomes
of all protocols was unfeasible due to missing treatment parameters and non-homogeneous
measurements.
Conclusions
The main barrier to optimizing clinical protocols of PBM for OM was the lack of standardization
in clinical studies. Although PBM use is now globally present in oncology settings
and generally marked by good outcomes reported, additional randomized clinical trials
with well-described methodologies are necessary.
Keywords
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Article info
Publication history
Accepted:
December 20,
2022
Received in revised form:
December 12,
2022
Received:
July 29,
2022
Publication stage
In Press Journal Pre-ProofIdentification
Copyright
© 2022 Elsevier Inc. All rights reserved.
