Abstract
Purpose
To evaluate the clinical outcomes of dental implants (DIs) in head and neck cancer
(HNC) patients treated with radiotherapy (RT), isolated chemotherapy or bone modifying
agents (BMAs)
Methods
This study was registered in PROSPERO (CRD42018102772), conducted via the PRISMA checklist,
and based on PubMed, Scopus, Embase, Cochrane Library, Web of Science, and gray literature
searches. The selection of studies was performed in two phases by two independent
reviewers. The risk of bias (RoB) was assessed by the Measurement Tool to Assess the
Methodological Quality of Systematic Reviews 2 (AMSTAR 2)
Results
Twenty systematic reviews were included in the qualitative analysis. The majority
scored as having high RoB (n=11). Primary DIs placement in the mandible of HNC patients
subjected to RT doses <50 Gy was associated with better survival rates
Conclusions
DIs placement could be considered safe in HNC patients in sites of alveolar bone that
received RT (≤5,000 Gy); however, no conclusions could be made in cancer patients
managed by chemotherapy or BMAs. Due to the heterogeneity of studies included, the
recommendation for DIs placement in cancer patients should be carefully considered.
Future better controlled randomized clinical trials are required to provide enhanced
clinical guidelines for best patient care.
Keywords
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Article info
Publication history
Accepted:
January 17,
2023
Received in revised form:
January 3,
2023
Received:
September 1,
2022
Publication stage
In Press Journal Pre-ProofIdentification
Copyright
© 2023 Published by Elsevier Inc.
