Objective
The aim of this study was to evaluate the clinical outcomes of dental implants (DIs)
in patients with head and neck cancer (HNC) treated with radiotherapy (RT), isolated
chemotherapy, or bone modifying agents (BMAs).
Study Design
This study was registered in the Prospective Register of Systematic Reviews (CRD42018102772);
conducted via the Preferred Reporting Items for Systematic Reviews and Meta-Analyses
checklist; and based on PubMed, Scopus, Embase, Cochrane Library, Web of Science,
and gray literature searches. The selection of studies was performed in 2 phases by
2 independent reviewers. The risk of bias (RoB) was assessed by the Measurement Tool
to Assess the Methodological Quality of Systematic Reviews 2.
Results
Twenty systematic reviews were included in the qualitative analysis. The majority
scored as having high RoB (n = 11). Primary DIs placement in the mandible of patients
with HNC subjected to RT doses <50 Gy was associated with better survival rates.
Conclusions
The placements of DIs could be considered safe in patients with HNC in sites of alveolar
bone that received RT (≤5000 Gy); however, no conclusions could be made in patients
with cancer managed by chemotherapy or BMAs. Due to the heterogeneity of studies included,
the recommendation for DIs placement in patients with cancer should be carefully considered.
Future better controlled randomized clinical trials are required to provide enhanced
clinical guidelines for best patient care.
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Article info
Publication history
Published online: January 25, 2023
Accepted:
January 17,
2023
Received in revised form:
January 3,
2023
Received:
September 1,
2022
Publication stage
In Press Journal Pre-ProofIdentification
Copyright
© 2023 Elsevier Inc. All rights reserved.
