Objective
The aim of this study was to investigate and compare the immunohistochemical expression
of connexin 43 (Cx43) in tooth germs (TGs), ameloblastic fibromas (AFs), ameloblastic
fibro-odontomas (AFOs), and conventional ameloblastomas (AMs).
Study Design
Nine TGs, 12 AFs, 12 AFOs, and 27 AMs were evaluated for Cx43 expression by immunohistochemistry.
Results
Most of the TGs expressed Cx43 in the mesenchyme (77.6%) and in the late stages of
odontogenesis. Cx43 was more highly expressed (P < .05) in the mesenchymal layer of all groups than in the epithelial layer except for
the AFOs. When comparing the expression of Cx43 in the different layers of the analyzed
groups, statistically significant differences were observed between AFO vs AM (*P = .0158) in the epithelial layer and between AF vs AFO (P** = .0046) in the mesenchymal layer.
Conclusions
The results obtained in this study showed that Cx43 is a protein with important expression
in the mesenchymal layer of the embryonic and odontogenic tissues studied. It could
be speculated that Cx43 participates in mineralization events based on the relationship
of the expression of this protein between the epithelial and mesenchymal layers of
odontogenic tissues.
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Article info
Publication history
Published online: January 31, 2023
Accepted:
January 25,
2023
Received in revised form:
October 28,
2022
Received:
September 14,
2022
Publication stage
In Press Journal Pre-ProofIdentification
Copyright
© 2023 Elsevier Inc. All rights reserved.
