ABSTRACT
Objectives
This study aims to quantitatively evaluate the effects of bisphosphonate use duration
and route of administration on mandibular cortical and trabecular bone in postmenopausal
women.
Study Design
90 postmenopausal women over the age of 50 were included in this study. Trabecular
bone density was specified numerically by fractal dimension (FD) in the region of
interest selected on the panoramic radiograph. The width of the mandibular cortical
(MCW) bone under the mental foramen of the mandible was measured. Mann-Whitney U test
was used for parameters that did not show normal distribution. Spearman's rho correlation
test was used to determine the relationship between continuous measurement parameters.
Results
It was observed that FD and MCW of dentate and edentate individuals using bisphosphonate
were statistically significantly lower than healthy individuals(p<0.05). There was
no significant correlation was found between the duration of use of bisphosphonates
and the fractal values obtained from the relevant regions of the mandible(p>0.05).
Conclusion
FD was found to be lower in Oral-Bisphosphonate use compared to use IV-Bisphosphonate.
MCW values were found to be lower in individuals using bisphosphonate than the healthy
individuals. FD and MCW may benefit clinicians as a quantitative parameter in panoramic
radiography in the diagnosis of osteoporosis.
Key words
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Article info
Publication history
Accepted:
February 17,
2023
Received in revised form:
February 2,
2023
Received:
November 15,
2022
Publication stage
In Press Journal Pre-ProofIdentification
Copyright
© 2023 Elsevier Inc. All rights reserved.
