This study aims to quantitatively evaluate the effects of bisphosphonate use duration and route of administration on mandibular cortical and trabecular bone in postmenopausal women.
90 postmenopausal women over the age of 50 were included in this study. Trabecular bone density was specified numerically by fractal dimension (FD) in the region of interest selected on the panoramic radiograph. The width of the mandibular cortical (MCW) bone under the mental foramen of the mandible was measured. Mann-Whitney U test was used for parameters that did not show normal distribution. Spearman's rho correlation test was used to determine the relationship between continuous measurement parameters.
It was observed that FD and MCW of dentate and edentate individuals using bisphosphonate were statistically significantly lower than healthy individuals(p<0.05). There was no significant correlation was found between the duration of use of bisphosphonates and the fractal values obtained from the relevant regions of the mandible(p>0.05).
FD was found to be lower in Oral-Bisphosphonate use compared to use IV-Bisphosphonate. MCW values were found to be lower in individuals using bisphosphonate than the healthy individuals. FD and MCW may benefit clinicians as a quantitative parameter in panoramic radiography in the diagnosis of osteoporosis.
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Accepted: February 17, 2023
Received in revised form: February 2, 2023
Received: November 15, 2022
Publication stageIn Press Journal Pre-Proof
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