Original Article|Articles in Press

A prospective, randomised, single-blind study to compare two methods of treating cystic lesions in the jaw

Published:February 23, 2023DOI:



      The aim of the study was to assess the usefulness of using a bovine bone substitute material in the treatment of cystic lesions in the jaw with a maximum diameter of < 4 cm.

      Material and methods

      In this prospective, randomised, single-blind intervention study of 116 patients, 61 underwent cystectomy with subsequent filling of the defect using a bovine xenograft, and 55 underwent cystectomy alone. Volumetric measurement of the cysts was performed preoperatively and 6 and 12 months postoperatively using the available digital volume tomography (DVT) data sets. Follow-up appointments were made after 14 days and 1, 3, 6 and 12 months postoperatively.


      Almost complete regeneration was seen in both treatment groups within 12 months, with no significant difference in absolute volume loss between the two groups (p = .521). Examination 14 days after surgery revealed a tendency for more wound healing disorders with the use of a bone substitute (p = .077). It was no longer possible to detect any further differences in later examinations.


      The use of a bovine bone substitute material has no radiologically measurable advantage over cystectomy alone without defect filling, with regard to bone regeneration. In addition, there was a tendency for more wound healing disorders to occur in the bone substitute group.


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