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This study is in accordance with the Declaration of Helsinki and was approved by the Piracicaba Dental Ethical Committee, Registration number CAAE: 42235421.9.0000.5418.
All authors have made substantial contributions to the conception (ALDA, ARSS), draft and design (ALDA, ESCS, ISPF, CSS, TBS), and review (MAL, PAV, ATP, LPK, ACPLFC, ARSS) of the paper's final version. The authors agree to be accountable for all aspects of the work and ensures that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Statement of clinical relevance
The interpretation and manual annotation of clinical images of oral leucoplakias can be very discrepant among oral medicine practitioners, affecting the quality of the final ground truth annotation that will drive image segmentation.