Original Article Oral Medicine|Articles in Press

Coexistence of Oral Lichen Planus and Vulvar Lichen Sclerosus

Published:March 08, 2023DOI:

      Statement of Clinical Relevance

      • We present the first study examining a cohort of patients with coexistent oral lichen planus and vulvar lichen sclerosus. Recognition of this noteworthy coexistence will benefit medical and dental clinicians treating patients with oral lichen planus and vulvar symptoms.



      Oral lichen planus is a mucosal variant of lichen planus. Lichen sclerosus is an inflammatory disorder with a predilection for genital skin. Our aim was to identify characteristics of patients with both mucosal diagnoses.

      Study Design

      This retrospective study included 86 women with both oral lichen planus and vulvar lichen sclerosus diagnosed from June 1, 1991, through November 30, 2020, at a Mayo Clinic campus in Rochester, Minnesota; Scottsdale, Arizona; or Jacksonville, Florida. Data included treatments, other cutaneous diagnoses, comorbidities, and information on patch testing and malignant transformation.


      The median patient age at diagnosis was 64.5 years for oral lichen planus and 65.6 years for vulvar lichen sclerosus. A diagnosis of oral lichen planus before vulvar lichen sclerosus was most common (50.0%). The most frequently used treatment for both conditions was topical corticosteroids. Oral squamous cell carcinoma did not develop in any patient, but vulvar squamous cell carcinoma developed in 2 (2.3%).


      Oral lichen planus and vulvar lichen sclerosus may coexist, commonly beginning in the patient's seventh decade. Topical corticosteroids are often used to manage both conditions. The coexistence of both diseases did not seem to portend a greater malignancy risk.



      LP (lichen planus), LS (lichen sclerosus), OLP (oral lichen planus), OPMD (oral potentially malignant disorder), SCC (squamous cell carcinoma)
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