Statement of Clinical Relevance
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We present the first study examining a cohort of patients with coexistent oral lichen planus and vulvar lichen sclerosus. Recognition of this noteworthy coexistence will benefit medical and dental clinicians treating patients with oral lichen planus and vulvar symptoms.
Abstract
Objective
Oral lichen planus is a mucosal variant of lichen planus. Lichen sclerosus is an inflammatory
disorder with a predilection for genital skin. Our aim was to identify characteristics
of patients with both mucosal diagnoses.
Study Design
This retrospective study included 86 women with both oral lichen planus and vulvar
lichen sclerosus diagnosed from June 1, 1991, through November 30, 2020, at a Mayo
Clinic campus in Rochester, Minnesota; Scottsdale, Arizona; or Jacksonville, Florida.
Data included treatments, other cutaneous diagnoses, comorbidities, and information
on patch testing and malignant transformation.
Results
The median patient age at diagnosis was 64.5 years for oral lichen planus and 65.6
years for vulvar lichen sclerosus. A diagnosis of oral lichen planus before vulvar
lichen sclerosus was most common (50.0%). The most frequently used treatment for both
conditions was topical corticosteroids. Oral squamous cell carcinoma did not develop
in any patient, but vulvar squamous cell carcinoma developed in 2 (2.3%).
Conclusions
Oral lichen planus and vulvar lichen sclerosus may coexist, commonly beginning in
the patient's seventh decade. Topical corticosteroids are often used to manage both
conditions. The coexistence of both diseases did not seem to portend a greater malignancy
risk.
Keywords
Abbreviations:
LP (lichen planus), LS (lichen sclerosus), OLP (oral lichen planus), OPMD (oral potentially malignant disorder), SCC (squamous cell carcinoma)To read this article in full you will need to make a payment
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Article info
Publication history
Accepted:
February 26,
2023
Received in revised form:
February 22,
2023
Received:
December 5,
2022
Publication stage
In Press Journal Pre-ProofFootnotes
Publisher: To expedite proof approval, send proof via email to [email protected] ©2023 Mayo Foundation for Medical Education and Research
Identification
Copyright
© 2023 Elsevier Inc. All rights reserved.
