Abstract
Objective
Osteopontin (OPN) is aberrantly expressed in a variety of tumours. However, its role
and detailed mechanisms in head and neck squamous cell carcinoma (HNSCC) have not
been extensively described.
Study Design
Expression of OPN in head and neck squamous cell carcinoma was examined at the gene
and protein levels. The effect of cell proliferation ability was examined by CCK8,
colony formation assay, cell invasiveness by Transwell assay, the effect of OPN on
protein expression of Capase-3 and Bcl2 by Western blotting, and the expression of
p38MAPK signaling pathway by p38MAPK inhibitor SB203580.
Results
We found that OPN expression was higher in human HNSCC tissues than in adjacent tissues.
OPN may regulate the proliferation and invasion of HNSCC cells through the p38-MAPK
signaling pathway.
Discussion
Our study identifies an important role for OPN in HNSCC and further demonstrates that
it may regulate the proliferation and invasion of HNSCC cells through activation of
the p38-MAPK signaling pathway. oPN may be a promising prognostic and diagnostic indicator
as well as a potential target for cancer therapy.
Clinical Relevance
Our study identifies a moderating role for OPN in the progression of HNSCC, and OPN
may be a promising potential indicator for diagnosis and prognosis.
Keywords
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Article info
Publication history
Accepted:
March 6,
2023
Received in revised form:
February 5,
2023
Received:
August 6,
2022
Publication stage
In Press Journal Pre-ProofIdentification
Copyright
© 2023 Published by Elsevier Inc.
