Osteopontin (OPN) is aberrantly expressed in a variety of tumours. However, its role and detailed mechanisms in head and neck squamous cell carcinoma (HNSCC) have not been extensively described.
Expression of OPN in head and neck squamous cell carcinoma was examined at the gene and protein levels. The effect of cell proliferation ability was examined by CCK8, colony formation assay, cell invasiveness by Transwell assay, the effect of OPN on protein expression of Capase-3 and Bcl2 by Western blotting, and the expression of p38MAPK signaling pathway by p38MAPK inhibitor SB203580.
We found that OPN expression was higher in human HNSCC tissues than in adjacent tissues. OPN may regulate the proliferation and invasion of HNSCC cells through the p38-MAPK signaling pathway.
Our study identifies an important role for OPN in HNSCC and further demonstrates that it may regulate the proliferation and invasion of HNSCC cells through activation of the p38-MAPK signaling pathway. oPN may be a promising prognostic and diagnostic indicator as well as a potential target for cancer therapy.
Our study identifies a moderating role for OPN in the progression of HNSCC, and OPN may be a promising potential indicator for diagnosis and prognosis.
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Accepted: March 6, 2023
Received in revised form: February 5, 2023
Received: August 6, 2022
Publication stageIn Press Journal Pre-Proof
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