In June 2017, a 52-year-old male patient was referred by his nephrologist to the Dental Service of the Clinics Hospital of the Federal University of Minas Gerais (HC-UFMG) for evaluation of an asymptomatic swelling in the tongue. The patient reported rapid enlargement of a swelling on the posterior region of his tongue; the swelling had started a few days ago. The patient denied any pain or discomfort. He had a medical history significant for end-stage renal disease (ESRD) caused by focal segmental glomerulosclerosis diagnosed 20 years ago.